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Evolution of recombination and genome structure in eusocial insects

Eusocial Hymenoptera, such as the European honey bee, Apis mellifera, have the highest recombination rates of multicellular animals.(1) Recently, we showed(2) that a side-effect of recombination in the honey bee, GC biased gene conversion (bGC), helps maintain the unusual bimodal GC-content distribu...

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Autores principales: Kent, Clement F., Zayed, Amro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609837/
https://www.ncbi.nlm.nih.gov/pubmed/23748924
http://dx.doi.org/10.4161/cib.22919
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author Kent, Clement F.
Zayed, Amro
author_facet Kent, Clement F.
Zayed, Amro
author_sort Kent, Clement F.
collection PubMed
description Eusocial Hymenoptera, such as the European honey bee, Apis mellifera, have the highest recombination rates of multicellular animals.(1) Recently, we showed(2) that a side-effect of recombination in the honey bee, GC biased gene conversion (bGC), helps maintain the unusual bimodal GC-content distribution of the bee genome by increasing GC-content in high recombination areas while low recombination areas are losing GC-content because of biased AT mutations and low rates of bGC. Although the very high recombination rate of A. mellifera makes GC-content evolution easier to study, the pattern is consistent with results found in many other species including mammals and yeast.(3) Also consistent across phyla is the association of higher genetic diversity and divergence with high GC and high recombination areas.(4)(,)(5) Finally, we showed that genes overexpressed in the brains of workers cluster in GC-rich genomic areas with the highest rates of recombination and molecular evolution.(2) In this Addendum we present a conceptual model of how eusociality and high recombination rates may co-evolve.
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spelling pubmed-36098372013-06-07 Evolution of recombination and genome structure in eusocial insects Kent, Clement F. Zayed, Amro Commun Integr Biol Article Addendum Eusocial Hymenoptera, such as the European honey bee, Apis mellifera, have the highest recombination rates of multicellular animals.(1) Recently, we showed(2) that a side-effect of recombination in the honey bee, GC biased gene conversion (bGC), helps maintain the unusual bimodal GC-content distribution of the bee genome by increasing GC-content in high recombination areas while low recombination areas are losing GC-content because of biased AT mutations and low rates of bGC. Although the very high recombination rate of A. mellifera makes GC-content evolution easier to study, the pattern is consistent with results found in many other species including mammals and yeast.(3) Also consistent across phyla is the association of higher genetic diversity and divergence with high GC and high recombination areas.(4)(,)(5) Finally, we showed that genes overexpressed in the brains of workers cluster in GC-rich genomic areas with the highest rates of recombination and molecular evolution.(2) In this Addendum we present a conceptual model of how eusociality and high recombination rates may co-evolve. Landes Bioscience 2013-03-01 /pmc/articles/PMC3609837/ /pubmed/23748924 http://dx.doi.org/10.4161/cib.22919 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Article Addendum
Kent, Clement F.
Zayed, Amro
Evolution of recombination and genome structure in eusocial insects
title Evolution of recombination and genome structure in eusocial insects
title_full Evolution of recombination and genome structure in eusocial insects
title_fullStr Evolution of recombination and genome structure in eusocial insects
title_full_unstemmed Evolution of recombination and genome structure in eusocial insects
title_short Evolution of recombination and genome structure in eusocial insects
title_sort evolution of recombination and genome structure in eusocial insects
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609837/
https://www.ncbi.nlm.nih.gov/pubmed/23748924
http://dx.doi.org/10.4161/cib.22919
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