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At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi?
The recent discovery of introner-like elements (ILEs) in six fungal species shed new light on the origin of regular spliceosomal introns (RSIs) and the mechanism of intron gains. These novel spliceosomal introns are found in hundreds of copies, are longer than RSIs and harbor stable predicted second...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609843/ https://www.ncbi.nlm.nih.gov/pubmed/23750299 http://dx.doi.org/10.4161/cib.23147 |
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author | Collemare, Jérôme van der Burgt, Ate de Wit, Pierre J.G.M. |
author_facet | Collemare, Jérôme van der Burgt, Ate de Wit, Pierre J.G.M. |
author_sort | Collemare, Jérôme |
collection | PubMed |
description | The recent discovery of introner-like elements (ILEs) in six fungal species shed new light on the origin of regular spliceosomal introns (RSIs) and the mechanism of intron gains. These novel spliceosomal introns are found in hundreds of copies, are longer than RSIs and harbor stable predicted secondary structures. Yet, they are prone to degeneration in sequence and length to become undistinguishable from RSIs, suggesting that ILEs are predecessors of most RSIs. In most fungi, other near-identical introns were found duplicated in lower numbers in the same gene or in unrelated genes, indicating that intron duplication is a widespread phenomenon. However, ILEs are associated with the majority of intron gains, suggesting that the other types of duplication are of minor importance to the overall gains of introns. Our data support the hypothesis that ILEs’ multiplication corresponds to the main mechanism of intron gain in fungi. |
format | Online Article Text |
id | pubmed-3609843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36098432013-06-07 At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi? Collemare, Jérôme van der Burgt, Ate de Wit, Pierre J.G.M. Commun Integr Biol Short Communication The recent discovery of introner-like elements (ILEs) in six fungal species shed new light on the origin of regular spliceosomal introns (RSIs) and the mechanism of intron gains. These novel spliceosomal introns are found in hundreds of copies, are longer than RSIs and harbor stable predicted secondary structures. Yet, they are prone to degeneration in sequence and length to become undistinguishable from RSIs, suggesting that ILEs are predecessors of most RSIs. In most fungi, other near-identical introns were found duplicated in lower numbers in the same gene or in unrelated genes, indicating that intron duplication is a widespread phenomenon. However, ILEs are associated with the majority of intron gains, suggesting that the other types of duplication are of minor importance to the overall gains of introns. Our data support the hypothesis that ILEs’ multiplication corresponds to the main mechanism of intron gain in fungi. Landes Bioscience 2013-03-01 /pmc/articles/PMC3609843/ /pubmed/23750299 http://dx.doi.org/10.4161/cib.23147 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Short Communication Collemare, Jérôme van der Burgt, Ate de Wit, Pierre J.G.M. At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi? |
title | At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi? |
title_full | At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi? |
title_fullStr | At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi? |
title_full_unstemmed | At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi? |
title_short | At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi? |
title_sort | at the origin of spliceosomal introns: is multiplication of introner-like elements the main mechanism of intron gain in fungi? |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609843/ https://www.ncbi.nlm.nih.gov/pubmed/23750299 http://dx.doi.org/10.4161/cib.23147 |
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