Conditional Deletion of Jak2 Reveals an Essential Role in Hematopoiesis throughout Mouse Ontogeny: Implications for Jak2 Inhibition in Humans

Germline deletion of Jak2 in mice results in embryonic lethality at E12.5 due to impaired hematopoiesis. However, the role that Jak2 might play in late gestation and postnatal life is unknown. To understand this, we utilized a conditional knockout approach that allowed for the deletion of Jak2 at va...

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Detalles Bibliográficos
Autores principales: Park, Sung O., Wamsley, Heather L., Bae, Kyungmi, Hu, Zhongbo, Li, Xiaomiao, Choe, Se-woon, Slayton, William B., Oh, S. Paul, Wagner, Kay-Uwe, Sayeski, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609865/
https://www.ncbi.nlm.nih.gov/pubmed/23544085
http://dx.doi.org/10.1371/journal.pone.0059675

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