Interplay of LRRK2 with chaperone-mediated autophagy

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). In this work, we demonstrate that LRRK2 can be degraded in lysosomes by chaperone-mediated autophagy (CMA), whereas the most common pathogenic mutant form of LRRK2, G2019S, is poorly deg...

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Detalles Bibliográficos
Autores principales: Orenstein, Samantha J., Kuo, Sheng-Hang, Tasset, Inmaculada, Arias, Esperanza, Koga, Hiroshi, Fernandez-Carasa, Irene, Cortes, Etty, Honig, Lawrence S., Dauer, William, Consiglio, Antonella, Raya, Angel, Sulzer, David, Cuervo, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609872/
https://www.ncbi.nlm.nih.gov/pubmed/23455607
http://dx.doi.org/10.1038/nn.3350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609872/
https://www.ncbi.nlm.nih.gov/pubmed/23455607
http://dx.doi.org/10.1038/nn.3350

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