CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors

Stressors impact dopamine-dependent behaviors such as motivation, though the underlying neurobiological mechanism is not well defined. We report that corticotropin-releasing factor (CRF) acts within the ventral tegmental area (VTA) to reduce the motivation to work for food rewards. CRF in the VTA re...

Descripción completa

Detalles Bibliográficos
Autores principales: Wanat, Matthew J., Bonci, Antonello, Phillips, Paul E. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609940/
https://www.ncbi.nlm.nih.gov/pubmed/23416448
http://dx.doi.org/10.1038/nn.3335
_version_ 1782264383381962752
author Wanat, Matthew J.
Bonci, Antonello
Phillips, Paul E. M.
author_facet Wanat, Matthew J.
Bonci, Antonello
Phillips, Paul E. M.
author_sort Wanat, Matthew J.
collection PubMed
description Stressors impact dopamine-dependent behaviors such as motivation, though the underlying neurobiological mechanism is not well defined. We report that corticotropin-releasing factor (CRF) acts within the ventral tegmental area (VTA) to reduce the motivation to work for food rewards. CRF in the VTA regulates dopamine output in a stimulus- and pathway-specific manner, collectively offering a mechanism by which acute stress selectively regulates information transmission via the VTA to reprioritize motivated behavior.
format Online
Article
Text
id pubmed-3609940
institution National Center for Biotechnology Information
language English
publishDate 2013
record_format MEDLINE/PubMed
spelling pubmed-36099402013-10-01 CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors Wanat, Matthew J. Bonci, Antonello Phillips, Paul E. M. Nat Neurosci Article Stressors impact dopamine-dependent behaviors such as motivation, though the underlying neurobiological mechanism is not well defined. We report that corticotropin-releasing factor (CRF) acts within the ventral tegmental area (VTA) to reduce the motivation to work for food rewards. CRF in the VTA regulates dopamine output in a stimulus- and pathway-specific manner, collectively offering a mechanism by which acute stress selectively regulates information transmission via the VTA to reprioritize motivated behavior. 2013-02-17 2013-04 /pmc/articles/PMC3609940/ /pubmed/23416448 http://dx.doi.org/10.1038/nn.3335 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wanat, Matthew J.
Bonci, Antonello
Phillips, Paul E. M.
CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
title CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
title_full CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
title_fullStr CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
title_full_unstemmed CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
title_short CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
title_sort crf acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609940/
https://www.ncbi.nlm.nih.gov/pubmed/23416448
http://dx.doi.org/10.1038/nn.3335
work_keys_str_mv AT wanatmatthewj crfactsinthemidbraintoattenuateaccumbensdopaminereleasetorewardsbutnottheirpredictors
AT bonciantonello crfactsinthemidbraintoattenuateaccumbensdopaminereleasetorewardsbutnottheirpredictors
AT phillipspaulem crfactsinthemidbraintoattenuateaccumbensdopaminereleasetorewardsbutnottheirpredictors

Ejemplares similares