Cargando…

Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?

The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent gonadotropin-releasing hormone secretagogues produced by two main populat...

Descripción completa

Detalles Bibliográficos
Autores principales: Franceschini, Isabelle, Desroziers, Elodie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610010/
https://www.ncbi.nlm.nih.gov/pubmed/23543285
http://dx.doi.org/10.3389/fendo.2013.00022
_version_ 1782264388454973440
author Franceschini, Isabelle
Desroziers, Elodie
author_facet Franceschini, Isabelle
Desroziers, Elodie
author_sort Franceschini, Isabelle
collection PubMed
description The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent gonadotropin-releasing hormone secretagogues produced by two main populations of neurons located in two ventral forebrain regions, the preoptic area and the arcuate nucleus. Within the last 2 years a substantial amount of data has accumulated concerning the development of these neuronal populations and their timely regulation by central and peripheral factors during fetal, neonatal, and peripubertal stages of development. This review focuses on the development of the kisspeptin–GPR54 system in the brain of female mice, rats, sheep, monkeys, and humans. We will also discuss the notion that this system represents a major target through which signals from the environment early in life can reprogram reproductive function.
format Online
Article
Text
id pubmed-3610010
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36100102013-03-29 Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function? Franceschini, Isabelle Desroziers, Elodie Front Endocrinol (Lausanne) Endocrinology The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent gonadotropin-releasing hormone secretagogues produced by two main populations of neurons located in two ventral forebrain regions, the preoptic area and the arcuate nucleus. Within the last 2 years a substantial amount of data has accumulated concerning the development of these neuronal populations and their timely regulation by central and peripheral factors during fetal, neonatal, and peripubertal stages of development. This review focuses on the development of the kisspeptin–GPR54 system in the brain of female mice, rats, sheep, monkeys, and humans. We will also discuss the notion that this system represents a major target through which signals from the environment early in life can reprogram reproductive function. Frontiers Media S.A. 2013-03-28 /pmc/articles/PMC3610010/ /pubmed/23543285 http://dx.doi.org/10.3389/fendo.2013.00022 Text en Copyright © 2013 Franceschini and Desroziers. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Endocrinology
Franceschini, Isabelle
Desroziers, Elodie
Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
title Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
title_full Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
title_fullStr Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
title_full_unstemmed Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
title_short Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
title_sort development and aging of the kisspeptin–gpr54 system in the mammalian brain: what are the impacts on female reproductive function?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610010/
https://www.ncbi.nlm.nih.gov/pubmed/23543285
http://dx.doi.org/10.3389/fendo.2013.00022
work_keys_str_mv AT franceschiniisabelle developmentandagingofthekisspeptingpr54systeminthemammalianbrainwhataretheimpactsonfemalereproductivefunction
AT desrozierselodie developmentandagingofthekisspeptingpr54systeminthemammalianbrainwhataretheimpactsonfemalereproductivefunction