PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha

BACKGROUND: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatase having both protein and lipid phosphatase activities, and is known to antagonize the phosphoinositide 3-kinase/AKT (PI3K/AKT) signaling pathway, resulting in tumor suppression. PTEN is also known to play a...

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Detalles Bibliográficos
Autores principales: Yang, Chunhua, Li, Shujing, Wang, Miao, Chang, Alan K, Liu, Ying, Zhao, Feng, Xiao, Liyun, Han, Lin, Wang, Dao, Li, Shen, Wu, Huijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610140/
https://www.ncbi.nlm.nih.gov/pubmed/23514585
http://dx.doi.org/10.1186/1476-4598-12-21

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