Cargando…
Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan
BACKGROUND: The US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonization in US military personnel. METHODS: GNB colonization surveillance of healthy,...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610270/ https://www.ncbi.nlm.nih.gov/pubmed/23384348 http://dx.doi.org/10.1186/1471-2334-13-68 |
_version_ | 1782264432471048192 |
---|---|
author | Vento, Todd J Cole, David W Mende, Katrin Calvano, Tatjana P Rini, Elizabeth A Tully, Charla C Zera, Wendy C Guymon, Charles H Yu, Xin Cheatle, Kristelle A Akers, Kevin S Beckius, Miriam L Landrum, Michael L Murray, Clinton K |
author_facet | Vento, Todd J Cole, David W Mende, Katrin Calvano, Tatjana P Rini, Elizabeth A Tully, Charla C Zera, Wendy C Guymon, Charles H Yu, Xin Cheatle, Kristelle A Akers, Kevin S Beckius, Miriam L Landrum, Michael L Murray, Clinton K |
author_sort | Vento, Todd J |
collection | PubMed |
description | BACKGROUND: The US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonization in US military personnel. METHODS: GNB colonization surveillance of healthy, asymptomatic military personnel (101 in the US and 100 in Afghanistan) was performed by swabbing 7 anatomical sites. US-based personnel had received no antibiotics within 30 days of specimen collection, and Afghanistan-based personnel were receiving doxycycline for malaria chemoprophylaxis at time of specimen collection. Isolates underwent genotypic and phenotypic characterization. RESULTS: The only colonizing MDR GNB recovered in both populations was Escherichia coli (p=0.01), which was seen in 2% of US-based personnel (all perirectal) and 11% of Afghanistan-based personnel (10 perirectal, 1 foot+groin). Individuals with higher off-base exposures in Afghanistan did not show a difference in overall GNB colonization or MDR E. coli colonization, compared with those with limited off-base exposures. CONCLUSION: Healthy US- and Afghanistan-based military personnel have community onset-MDR E. coli colonization, with Afghanistan-based personnel showing a 5.5-fold higher prevalence. The association of doxycycline prophylaxis or other exposures with antimicrobial resistance and increased rates of MDR E. coli colonization needs further evaluation. |
format | Online Article Text |
id | pubmed-3610270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36102702013-03-29 Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan Vento, Todd J Cole, David W Mende, Katrin Calvano, Tatjana P Rini, Elizabeth A Tully, Charla C Zera, Wendy C Guymon, Charles H Yu, Xin Cheatle, Kristelle A Akers, Kevin S Beckius, Miriam L Landrum, Michael L Murray, Clinton K BMC Infect Dis Research Article BACKGROUND: The US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonization in US military personnel. METHODS: GNB colonization surveillance of healthy, asymptomatic military personnel (101 in the US and 100 in Afghanistan) was performed by swabbing 7 anatomical sites. US-based personnel had received no antibiotics within 30 days of specimen collection, and Afghanistan-based personnel were receiving doxycycline for malaria chemoprophylaxis at time of specimen collection. Isolates underwent genotypic and phenotypic characterization. RESULTS: The only colonizing MDR GNB recovered in both populations was Escherichia coli (p=0.01), which was seen in 2% of US-based personnel (all perirectal) and 11% of Afghanistan-based personnel (10 perirectal, 1 foot+groin). Individuals with higher off-base exposures in Afghanistan did not show a difference in overall GNB colonization or MDR E. coli colonization, compared with those with limited off-base exposures. CONCLUSION: Healthy US- and Afghanistan-based military personnel have community onset-MDR E. coli colonization, with Afghanistan-based personnel showing a 5.5-fold higher prevalence. The association of doxycycline prophylaxis or other exposures with antimicrobial resistance and increased rates of MDR E. coli colonization needs further evaluation. BioMed Central 2013-02-05 /pmc/articles/PMC3610270/ /pubmed/23384348 http://dx.doi.org/10.1186/1471-2334-13-68 Text en Copyright ©2013 Vento et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vento, Todd J Cole, David W Mende, Katrin Calvano, Tatjana P Rini, Elizabeth A Tully, Charla C Zera, Wendy C Guymon, Charles H Yu, Xin Cheatle, Kristelle A Akers, Kevin S Beckius, Miriam L Landrum, Michael L Murray, Clinton K Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan |
title | Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan |
title_full | Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan |
title_fullStr | Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan |
title_full_unstemmed | Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan |
title_short | Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan |
title_sort | multidrug-resistant gram-negative bacteria colonization of healthy us military personnel in the us and afghanistan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610270/ https://www.ncbi.nlm.nih.gov/pubmed/23384348 http://dx.doi.org/10.1186/1471-2334-13-68 |
work_keys_str_mv | AT ventotoddj multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT coledavidw multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT mendekatrin multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT calvanotatjanap multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT rinielizabetha multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT tullycharlac multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT zerawendyc multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT guymoncharlesh multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT yuxin multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT cheatlekristellea multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT akerskevins multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT beckiusmiriaml multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT landrummichaell multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan AT murrayclintonk multidrugresistantgramnegativebacteriacolonizationofhealthyusmilitarypersonnelintheusandafghanistan |