Prophage Induction Is Enhanced and Required for Renal Disease and Lethality in an EHEC Mouse Model

Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. A...

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Detalles Bibliográficos
Autores principales: Tyler, Jessica S., Beeri, Karen, Reynolds, Jared L., Alteri, Christopher J., Skinner, Katherine G., Friedman, Jonathan H., Eaton, Kathryn A., Friedman, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610611/
https://www.ncbi.nlm.nih.gov/pubmed/23555250
http://dx.doi.org/10.1371/journal.ppat.1003236

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