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Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on mul...

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Detalles Bibliográficos
Autores principales:	Mukhopadhyay, Himadri, Cordoba, Shaun-Paul, Maini, Philip K., van der Merwe, P. Anton, Dushek, Omer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610635/ https://www.ncbi.nlm.nih.gov/pubmed/23555234 http://dx.doi.org/10.1371/journal.pcbi.1003004

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