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Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans

BACKGROUND: Mycolactones are a family of polyketide-derived macrolide exotoxins produced by Mycobacterium ulcerans, the causative agent of the chronic necrotizing skin disease Buruli ulcer. The toxin is synthesized by polyketide synthases encoded by the virulence plasmid pMUM. The apoptotic, necroti...

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Detalles Bibliográficos
Autores principales:	Scherr, Nicole, Gersbach, Philipp, Dangy, Jean-Pierre, Bomio, Claudio, Li, Jun, Altmann, Karl-Heinz, Pluschke, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610637/ https://www.ncbi.nlm.nih.gov/pubmed/23556027 http://dx.doi.org/10.1371/journal.pntd.0002143

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