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Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice
CTNNBL1 is an armadillo-repeat protein that associates with the CDC5L/Prp19 complex of the spliceosome. Unlike the majority of spliceosomal proteins (and despite having no obvious homologs), CTNNBL1 is inessential for cell viability as revealed by studies in both vertebrate B cell lines and in fissi...
Autores principales: | Chandra, Anita, van Maldegem, Febe, Andrews, Simon, Neuberger, Michael S., Rada, Cristina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610721/ https://www.ncbi.nlm.nih.gov/pubmed/23343763 http://dx.doi.org/10.4161/cc.23594 |
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