Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice

Ptch1 is a key regulator of embryonic development, acting through the sonic hedgehog (SHH) signaling pathway. Ptch1 is best known as a tumor suppressor, since germline or somatic mutations in Ptch1 lead to the formation of skin basal cell carcinomas (BCCs). Here, we show that Ptch1 also acts as a li...

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Detalles Bibliográficos
Autores principales: Kang, Hio Chung, Wakabayashi, Yuichi, Jen, Kuang-Yu, Mao, Jian-Hua, Zoumpourlis, Vassilis, Rosario, Reyno Del, Balmain, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610826/
https://www.ncbi.nlm.nih.gov/pubmed/23223138
http://dx.doi.org/10.1038/jid.2012.419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610826/
https://www.ncbi.nlm.nih.gov/pubmed/23223138
http://dx.doi.org/10.1038/jid.2012.419

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