Cargando…

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson’s disease and depression

Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson’s disease as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression. Model genetic organisms such as Drosophila melanogaster may enhance the detection of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lawal, Hakeem O., Terrell, Ashley, Lam, Hoa A., Djapri, Christine, Jang, Jennifer, Hadi, Richard, Roberts, Logan, Shahi, Varun, Chou, Man-Ting, Biedermann, Traci, Huang, Brian, Lawless, George M., Maidment, Nigel T., Krantz, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610854/ https://www.ncbi.nlm.nih.gov/pubmed/23229049 http://dx.doi.org/10.1038/mp.2012.170

Ejemplares similares

Aminergic Signaling Controls Ovarian Dormancy in Drosophila
por: Andreatta, Gabriele, et al.
Publicado: (2018)

Neuromuscular organization and aminergic modulation of contractions in the Drosophila ovary
por: Middleton, C Adam, et al.
Publicado: (2006)

Neuroarchitecture of Aminergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster
por: Vömel, Matthias, et al.
Publicado: (2008)

Effect of aminergic signaling on the humoral innate immunity response of Drosophila
por: Cattabriga, Giulia, et al.
Publicado: (2023)

Zinc Toxicity to Aminergic Neurotransmitters in Rat Brain
por: Kumar, M. Vijaya, et al.
Publicado: (2010)

Aminergic Control of Social Status in Crayfish Agonistic Encounters
por: Momohara, Yuto, et al.
Publicado: (2013)

Roles of Aminergic Neurons in Formation and Recall of Associative Memory in Crickets
por: Mizunami, Makoto, et al.
Publicado: (2010)

Origins of Aminergic Regulation of Behavior in Complex Insect Social Systems
por: Kamhi, J. Frances, et al.
Publicado: (2017)

Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins
por: Blanchet, Guillaume, et al.
Publicado: (2017)

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
por: McCorvy, John D., et al.
Publicado: (2017)

The trace aminergic system: a gender-sensitive therapeutic target for IBS?
por: Pretorius, Lesha, et al.
Publicado: (2020)

Emotional Roles of Mono-Aminergic Neurotransmitters in Major Depressive Disorder and Anxiety Disorders
por: Liu, Yi, et al.
Publicado: (2018)

Three-dimensional descriptors for aminergic GPCRs: dependence on docking conformation and crystal structure
por: Jastrzębski, Stanisław, et al.
Publicado: (2018)

Data-Driven Analysis of Fluorination of Ligands of Aminergic G Protein Coupled Receptors
por: Pietruś, Wojciech, et al.
Publicado: (2021)

Data on the specificity of an antibody to Drosophila vesicular acetylcholine transporter
por: Boppana, Sridhar, et al.
Publicado: (2017)

Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
por: Ferruz, Noelia, et al.
Publicado: (2018)

Evolutionary association of receptor-wide amino acids with G protein–coupling selectivity in aminergic GPCRs
por: Selçuk, Berkay, et al.
Publicado: (2022)

Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice
por: Yang, Soo Hyun, et al.
Publicado: (2023)

Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
por: Ferruz, Noelia, et al.
Publicado: (2019)

Regulation and modulation of biogenic amine neurotransmission in Drosophila and Caenorhabditis elegans
por: Rosikon, Katarzyna D., et al.
Publicado: (2023)

Unraveling Synaptic GCaMP Signals: Differential Excitability and Clearance Mechanisms Underlying Distinct Ca(2+) Dynamics in Tonic and Phasic Excitatory, and Aminergic Modulatory Motor Terminals in Drosophila
por: Xing, Xiaomin, et al.
Publicado: (2018)

Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival
por: Fuchs, Silke, et al.
Publicado: (2014)

Isomeric Activity Cliffs—A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands
por: Pietruś, Wojciech, et al.
Publicado: (2023)

A Common Molecular Motif Characterizes Extracellular Allosteric Enhancers of GPCR Aminergic Receptors and Suggests Enhancer Mechanism of Action
por: Bernstein, Robert Root, et al.
Publicado: (2014)

Precise CRISPR-Cas9-mediated mutation of a membrane trafficking domain in the Drosophila vesicular monoamine transporter gene
por: Asuncion, James D., et al.
Publicado: (2023)

Erratum: Xing and Wu, “Unraveling Synaptic GCaMP Signals: Differential Excitability and Clearance Mechanisms Underlying Distinct Ca2+ Dynamics in Tonic and Phasic Excitatory, and Aminergic Modulatory Motor Terminals in Drosophila.”
Publicado: (2021)

A Glial Variant of the Vesicular Monoamine Transporter Is Required To Store Histamine in the Drosophila Visual System
por: Romero-Calderón, Rafael, et al.
Publicado: (2008)

Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2
por: Lam, Hoa, et al.
Publicado: (2011)

Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse
por: Root-Bernstein, Robert, et al.
Publicado: (2020)

Drosophila Cajal bodies: accessories not included
por: Matera, A. Gregory
Publicado: (2006)

Spatial Analysis of the Neuronal Density of Aminergic Brainstem Nuclei in Primary Neurodegenerative and Vascular Dementia: A Comparative Immunocytochemical and Quantitative Study Using a Graph Method
por: Yang, Yan, et al.
Publicado: (1999)

The Geomagnetic Field (GMF) Is Necessary for Black Garden Ant (Lasius niger L.) Foraging and Modulates Orientation Potentially through Aminergic Regulation and MagR Expression
por: Mannino, Giuseppe, et al.
Publicado: (2023)

Overview of the Complex Figure Test and Its Clinical Application in Neuropsychiatric Disorders, Including Copying and Recall
por: Zhang, Xiaonan, et al.
Publicado: (2021)

Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
por: Emole, Josephine, et al.
Publicado: (2023)

Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter
por: Bonanno, Shivan L., et al.
Publicado: (2023)

Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter
por: Bonanno, Shivan L., et al.
Publicado: (2023)

Transcriptomic Analysis in a Drosophila Model Identifies Previously Implicated and Novel Pathways in the Therapeutic Mechanism in Neuropsychiatric Disorders
por: Singh, Priyanka, et al.
Publicado: (2011)

Investigating cytosolic 5′-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr)
por: Singgih, Euginia L., et al.
Publicado: (2021)

International Neuropsychiatric Association
por: Sachdev, Perminder
Publicado: (2005)

Neuropsychiatric manifestations in CADASIL
por: Chabriat, Hugues, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_rtgsaeu7m3e89jk8lvnai9mrgs