Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost Is Mediated by Estrogen Receptor β

Mechanical strain and estrogens both stimulate osteoblast proliferation through estrogen receptor (ER)-mediated effects, and both down-regulate the Wnt antagonist Sost/sclerostin. Here, we investigate the differential effects of ERα and -β in these processes in mouse long bone-derived osteoblastic c...

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Detalles Bibliográficos
Autores principales: Galea, Gabriel L., Meakin, Lee B., Sugiyama, Toshihiro, Zebda, Noureddine, Sunters, Andrew, Taipaleenmaki, Hanna, Stein, Gary S., van Wijnen, Andre J., Lanyon, Lance E., Price, Joanna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610976/
https://www.ncbi.nlm.nih.gov/pubmed/23362266
http://dx.doi.org/10.1074/jbc.M112.405456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610976/
https://www.ncbi.nlm.nih.gov/pubmed/23362266
http://dx.doi.org/10.1074/jbc.M112.405456

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