Gastrin-induced proliferation involves MEK partner 1 (MP1)

The peptide hormone gastrin is an important factor for the maintenance and homeostasis of the gastric mucosa. We show that gastrin stimulates proliferation in a dose-dependent manner in the human gastric adenocarcinoma cell line AGS-G(R). Furthermore, we demonstrate that the MAPK scaffold protein ME...

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Detalles Bibliográficos
Autores principales: Steigedal, Tonje S., Prestvik, Wenche S., Selvik, Linn-Karina M., Fjeldbo, Christina S., Bruland, Torunn, Lægreid, Astrid, Thommesen, Liv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611038/
https://www.ncbi.nlm.nih.gov/pubmed/23408059
http://dx.doi.org/10.1007/s11626-013-9588-2
Descripción
Sumario:The peptide hormone gastrin is an important factor for the maintenance and homeostasis of the gastric mucosa. We show that gastrin stimulates proliferation in a dose-dependent manner in the human gastric adenocarcinoma cell line AGS-G(R). Furthermore, we demonstrate that the MAPK scaffold protein MEK partner 1 (MP1) is important for gastrin-induced phosphorylation of ERK1 and ERK2 and that MP1 promotes gastrin-induced proliferation of AGS-G(R) cells. Our results suggest a role of MP1 in gastrin-induced cellular responses involved in proliferation and homeostasis of the gastric mucosa.

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