Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats

The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 cons...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Rajendra Kumar, Banerjee, Rita, Upadhyay, Sachhidananda, Mitra, Achintya, Hazra, Jayram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Pharmacological Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611640/
https://www.ncbi.nlm.nih.gov/pubmed/23559809
http://dx.doi.org/10.4103/0974-8520.105257
_version_ 1782264553037365248
author Singh, Rajendra Kumar
Banerjee, Rita
Upadhyay, Sachhidananda
Mitra, Achintya
Hazra, Jayram
author_facet Singh, Rajendra Kumar
Banerjee, Rita
Upadhyay, Sachhidananda
Mitra, Achintya
Hazra, Jayram
author_sort Singh, Rajendra Kumar
collection PubMed
description The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations.
format Online
Article
Text
id pubmed-3611640
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-36116402013-04-04 Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats Singh, Rajendra Kumar Banerjee, Rita Upadhyay, Sachhidananda Mitra, Achintya Hazra, Jayram Ayu Pharmacological Study The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3611640/ /pubmed/23559809 http://dx.doi.org/10.4103/0974-8520.105257 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pharmacological Study
Singh, Rajendra Kumar
Banerjee, Rita
Upadhyay, Sachhidananda
Mitra, Achintya
Hazra, Jayram
Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats
title Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats
title_full Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats
title_fullStr Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats
title_full_unstemmed Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats
title_short Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats
title_sort toxicological evaluation of panchakola avaleha, an ayurvedic classical formulation, in albino rats
topic Pharmacological Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611640/
https://www.ncbi.nlm.nih.gov/pubmed/23559809
http://dx.doi.org/10.4103/0974-8520.105257
work_keys_str_mv AT singhrajendrakumar toxicologicalevaluationofpanchakolaavalehaanayurvedicclassicalformulationinalbinorats
AT banerjeerita toxicologicalevaluationofpanchakolaavalehaanayurvedicclassicalformulationinalbinorats
AT upadhyaysachhidananda toxicologicalevaluationofpanchakolaavalehaanayurvedicclassicalformulationinalbinorats
AT mitraachintya toxicologicalevaluationofpanchakolaavalehaanayurvedicclassicalformulationinalbinorats
AT hazrajayram toxicologicalevaluationofpanchakolaavalehaanayurvedicclassicalformulationinalbinorats

Ejemplares similares