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Is there a brainstem generator of chronic daily headache?

Using BOLD-fMRI we have previously documented activation of the red nucleus (RN) and substantia nigra (SN) during spontaneously and visually activated migraine headache. These observations prompted us to study brainstem function in chronic daily headache patients using high-resolution magnetic reson...

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Autores principales: Nagesh, Vijaya, Welch, Michael, Aurora, Sheena K., Gelman, Neil, Gopal, Shanthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag Italia 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611771/
http://dx.doi.org/10.1007/s101940070045
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author Nagesh, Vijaya
Welch, Michael
Aurora, Sheena K.
Gelman, Neil
Gopal, Shanthi
author_facet Nagesh, Vijaya
Welch, Michael
Aurora, Sheena K.
Gelman, Neil
Gopal, Shanthi
author_sort Nagesh, Vijaya
collection PubMed
description Using BOLD-fMRI we have previously documented activation of the red nucleus (RN) and substantia nigra (SN) during spontaneously and visually activated migraine headache. These observations prompted us to study brainstem function in chronic daily headache patients using high-resolution magnetic resonance imaging (MRI) techniques. Seventeen chronic daily headache (CDH) patients, ten episodic migraine (EM) patients and fifteen controls (N) were imaged with a 3 tesla MRI system. For each subject, the relaxation rates R2, R2* and R2' were obtained for RN and SN. There was a significant decrease in R2' and R2* values for RN and SN in CDH compared to N and EM groups (p < 0.05), but no significant difference between the N and EM groups. A decrease in R2' and R2* indicates reduced deoxyhemoglobin and hence persistent activation of the RN and SN in CDH patients most likely secondary to ongoing headache at the time of study. The imaging data provide objective evidence of disturbed central nervous system function in CDH.
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spelling pubmed-36117712013-04-01 Is there a brainstem generator of chronic daily headache? Nagesh, Vijaya Welch, Michael Aurora, Sheena K. Gelman, Neil Gopal, Shanthi J Headache Pain Enrico Greppi award paper Using BOLD-fMRI we have previously documented activation of the red nucleus (RN) and substantia nigra (SN) during spontaneously and visually activated migraine headache. These observations prompted us to study brainstem function in chronic daily headache patients using high-resolution magnetic resonance imaging (MRI) techniques. Seventeen chronic daily headache (CDH) patients, ten episodic migraine (EM) patients and fifteen controls (N) were imaged with a 3 tesla MRI system. For each subject, the relaxation rates R2, R2* and R2' were obtained for RN and SN. There was a significant decrease in R2' and R2* values for RN and SN in CDH compared to N and EM groups (p < 0.05), but no significant difference between the N and EM groups. A decrease in R2' and R2* indicates reduced deoxyhemoglobin and hence persistent activation of the RN and SN in CDH patients most likely secondary to ongoing headache at the time of study. The imaging data provide objective evidence of disturbed central nervous system function in CDH. Springer-Verlag Italia 2000-12 /pmc/articles/PMC3611771/ http://dx.doi.org/10.1007/s101940070045 Text en © Springer-Verlag Italia 2000
spellingShingle Enrico Greppi award paper
Nagesh, Vijaya
Welch, Michael
Aurora, Sheena K.
Gelman, Neil
Gopal, Shanthi
Is there a brainstem generator of chronic daily headache?
title Is there a brainstem generator of chronic daily headache?
title_full Is there a brainstem generator of chronic daily headache?
title_fullStr Is there a brainstem generator of chronic daily headache?
title_full_unstemmed Is there a brainstem generator of chronic daily headache?
title_short Is there a brainstem generator of chronic daily headache?
title_sort is there a brainstem generator of chronic daily headache?
topic Enrico Greppi award paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611771/
http://dx.doi.org/10.1007/s101940070045
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