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99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer

OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of th...

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Autores principales: Ribeiro, Monica Pires, de Souza, Sergio Augusto Lopes, Lopes, Flavia Paiva Proença Lobo, Rosado-de-Castro, Paulo Henrique, da Fonseca, Lea Mirian Barbosa, Gutfilen, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611895/
https://www.ncbi.nlm.nih.gov/pubmed/23644845
http://dx.doi.org/10.6061/clinics/2013(03)OA01
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author Ribeiro, Monica Pires
de Souza, Sergio Augusto Lopes
Lopes, Flavia Paiva Proença Lobo
Rosado-de-Castro, Paulo Henrique
da Fonseca, Lea Mirian Barbosa
Gutfilen, Bianca
author_facet Ribeiro, Monica Pires
de Souza, Sergio Augusto Lopes
Lopes, Flavia Paiva Proença Lobo
Rosado-de-Castro, Paulo Henrique
da Fonseca, Lea Mirian Barbosa
Gutfilen, Bianca
author_sort Ribeiro, Monica Pires
collection PubMed
description OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. CONCLUSIONS: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies.
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spelling pubmed-36118952013-04-05 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer Ribeiro, Monica Pires de Souza, Sergio Augusto Lopes Lopes, Flavia Paiva Proença Lobo Rosado-de-Castro, Paulo Henrique da Fonseca, Lea Mirian Barbosa Gutfilen, Bianca Clinics (Sao Paulo) Clinical Science OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. CONCLUSIONS: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2013-03 /pmc/articles/PMC3611895/ /pubmed/23644845 http://dx.doi.org/10.6061/clinics/2013(03)OA01 Text en Copyright © 2013 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Ribeiro, Monica Pires
de Souza, Sergio Augusto Lopes
Lopes, Flavia Paiva Proença Lobo
Rosado-de-Castro, Paulo Henrique
da Fonseca, Lea Mirian Barbosa
Gutfilen, Bianca
99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_full 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_fullStr 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_full_unstemmed 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_short 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_sort 99mtc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611895/
https://www.ncbi.nlm.nih.gov/pubmed/23644845
http://dx.doi.org/10.6061/clinics/2013(03)OA01
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