Identifying Resistance Mechanisms against Five Tyrosine Kinase Inhibitors Targeting the ERBB/RAS Pathway in 45 Cancer Cell Lines

Because of the low overall response rates of 10–47% to targeted cancer therapeutics, there is an increasing need for predictive biomarkers. We aimed to identify genes predicting response to five already approved tyrosine kinase inhibitors. We tested 45 cancer cell lines for sensitivity to sunitinib,...

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Detalles Bibliográficos
Autores principales: Pénzváltó, Zsófia, Tegze, Bálint, Szász, A. Marcell, Sztupinszki, Zsófia, Likó, István, Szendrői, Attila, Schäfer, Reinhold, Győrffy, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612034/
https://www.ncbi.nlm.nih.gov/pubmed/23555683
http://dx.doi.org/10.1371/journal.pone.0059503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612034/
https://www.ncbi.nlm.nih.gov/pubmed/23555683
http://dx.doi.org/10.1371/journal.pone.0059503

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