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Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease

Inflammatory mediators are closely associated with the pathogenesis of neurodegenerative changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Osteopontin (OPN) is a proinflammatory cytokine that has been shown to play an important role in various neuroinflammatory diseases....

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Autores principales: Sun, Yuan, Yin, Xue Song, Guo, Hong, Han, Rong Kun, He, Rui Dong, Chi, Li Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612435/
https://www.ncbi.nlm.nih.gov/pubmed/23576854
http://dx.doi.org/10.1155/2013/615745
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author Sun, Yuan
Yin, Xue Song
Guo, Hong
Han, Rong Kun
He, Rui Dong
Chi, Li Jun
author_facet Sun, Yuan
Yin, Xue Song
Guo, Hong
Han, Rong Kun
He, Rui Dong
Chi, Li Jun
author_sort Sun, Yuan
collection PubMed
description Inflammatory mediators are closely associated with the pathogenesis of neurodegenerative changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Osteopontin (OPN) is a proinflammatory cytokine that has been shown to play an important role in various neuroinflammatory diseases. However, the function of OPN in AD and MCI progression is not well defined. Cerebrospinal fluid (CSF) and plasma samples were obtained from 35 AD patients, 31 MCI patients, and 20 other noninflammatory neurologic diseases (OND). Concentrations of OPN in the CSF and plasma were determined by enzyme-linked immunosorbent assay. During a 3-year clinical followup, 13 MCI patients converted to AD (MCI converters), and 18 were clinically stable (MCI nonconverters). CSF OPN concentrations were significantly increased in AD and MCI converters compared to OND, and increased levels of OPN in AD were associated with MMSE score; OPN protein levels both in the CSF and plasma of newly diagnosed AD patients were higher than that of chronical patients. In MCI converters individuals tested longitudinally, both plasma and CSF OPN concentrations were significantly elevated when they received a diagnosis of AD during followup. Further wide-scale studies are necessary to confirm these results and to shed light on the etiopathogenic role of osteopontin in AD.
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spelling pubmed-36124352013-04-10 Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease Sun, Yuan Yin, Xue Song Guo, Hong Han, Rong Kun He, Rui Dong Chi, Li Jun Mediators Inflamm Clinical Study Inflammatory mediators are closely associated with the pathogenesis of neurodegenerative changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Osteopontin (OPN) is a proinflammatory cytokine that has been shown to play an important role in various neuroinflammatory diseases. However, the function of OPN in AD and MCI progression is not well defined. Cerebrospinal fluid (CSF) and plasma samples were obtained from 35 AD patients, 31 MCI patients, and 20 other noninflammatory neurologic diseases (OND). Concentrations of OPN in the CSF and plasma were determined by enzyme-linked immunosorbent assay. During a 3-year clinical followup, 13 MCI patients converted to AD (MCI converters), and 18 were clinically stable (MCI nonconverters). CSF OPN concentrations were significantly increased in AD and MCI converters compared to OND, and increased levels of OPN in AD were associated with MMSE score; OPN protein levels both in the CSF and plasma of newly diagnosed AD patients were higher than that of chronical patients. In MCI converters individuals tested longitudinally, both plasma and CSF OPN concentrations were significantly elevated when they received a diagnosis of AD during followup. Further wide-scale studies are necessary to confirm these results and to shed light on the etiopathogenic role of osteopontin in AD. Hindawi Publishing Corporation 2013 2013-03-14 /pmc/articles/PMC3612435/ /pubmed/23576854 http://dx.doi.org/10.1155/2013/615745 Text en Copyright © 2013 Yuan Sun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Sun, Yuan
Yin, Xue Song
Guo, Hong
Han, Rong Kun
He, Rui Dong
Chi, Li Jun
Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease
title Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease
title_full Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease
title_fullStr Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease
title_full_unstemmed Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease
title_short Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease
title_sort elevated osteopontin levels in mild cognitive impairment and alzheimer's disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612435/
https://www.ncbi.nlm.nih.gov/pubmed/23576854
http://dx.doi.org/10.1155/2013/615745
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