Cargando…

Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø

Data were pooled from four randomized clinical trials with vitamin D performed in Tromsø with weight reduction, insulin sensitivity, bone density, and depression scores as endpoints. Serum lipids, glycated hemoglobin (HbA(1c)), and high sensitivity C-Reactive Protein, (HS-CRP) were measured at basel...

Descripción completa

Detalles Bibliográficos
Autores principales: Jorde, Rolf, Strand Hutchinson, Moira, Kjærgaard, Marie, Sneve, Monica, Grimnes, Guri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612485/
https://www.ncbi.nlm.nih.gov/pubmed/23577264
http://dx.doi.org/10.1155/2013/348705
_version_ 1782264666618068992
author Jorde, Rolf
Strand Hutchinson, Moira
Kjærgaard, Marie
Sneve, Monica
Grimnes, Guri
author_facet Jorde, Rolf
Strand Hutchinson, Moira
Kjærgaard, Marie
Sneve, Monica
Grimnes, Guri
author_sort Jorde, Rolf
collection PubMed
description Data were pooled from four randomized clinical trials with vitamin D performed in Tromsø with weight reduction, insulin sensitivity, bone density, and depression scores as endpoints. Serum lipids, glycated hemoglobin (HbA(1c)), and high sensitivity C-Reactive Protein, (HS-CRP) were measured at baseline and after 6–12 months of supplementation with vitamin D 20 000 IU–40 000 IU per week versus placebo. A total of 928 subjects who completed the interventions were included. At baseline the mean serum 25-hydroxyvitamin D (25(OH)D) level in those given vitamin D was 55.9 (20.9) nmol/L and the mean increase was 82.4 (40.1) nmol/L. Compared with the placebo group there was in the vitamin D group at the end of the studies a slight, but significant, increase in HbA(1c) of 0.04%, an increase in HS-CRP of 0.07 mg/L in those with serum 25(OH)D < 50 nmol/L, and in those with low baseline HDL-C and serum 25(OH)D < 50 nmol/L a slight decrease serum HDL-C of 0.08 mmol/L (P < 0.05). No serious side-effects were seen. In conclusion, in subjects without vitamin D deficiency, there is no improvement in serum lipids, HbA(1c), or HS-CRP with high dose vitamin D supplementation. If anything, the effect is negative.
format Online
Article
Text
id pubmed-3612485
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36124852013-04-10 Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø Jorde, Rolf Strand Hutchinson, Moira Kjærgaard, Marie Sneve, Monica Grimnes, Guri ISRN Endocrinol Clinical Study Data were pooled from four randomized clinical trials with vitamin D performed in Tromsø with weight reduction, insulin sensitivity, bone density, and depression scores as endpoints. Serum lipids, glycated hemoglobin (HbA(1c)), and high sensitivity C-Reactive Protein, (HS-CRP) were measured at baseline and after 6–12 months of supplementation with vitamin D 20 000 IU–40 000 IU per week versus placebo. A total of 928 subjects who completed the interventions were included. At baseline the mean serum 25-hydroxyvitamin D (25(OH)D) level in those given vitamin D was 55.9 (20.9) nmol/L and the mean increase was 82.4 (40.1) nmol/L. Compared with the placebo group there was in the vitamin D group at the end of the studies a slight, but significant, increase in HbA(1c) of 0.04%, an increase in HS-CRP of 0.07 mg/L in those with serum 25(OH)D < 50 nmol/L, and in those with low baseline HDL-C and serum 25(OH)D < 50 nmol/L a slight decrease serum HDL-C of 0.08 mmol/L (P < 0.05). No serious side-effects were seen. In conclusion, in subjects without vitamin D deficiency, there is no improvement in serum lipids, HbA(1c), or HS-CRP with high dose vitamin D supplementation. If anything, the effect is negative. Hindawi Publishing Corporation 2013-03-14 /pmc/articles/PMC3612485/ /pubmed/23577264 http://dx.doi.org/10.1155/2013/348705 Text en Copyright © 2013 Rolf Jorde et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Jorde, Rolf
Strand Hutchinson, Moira
Kjærgaard, Marie
Sneve, Monica
Grimnes, Guri
Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø
title Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø
title_full Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø
title_fullStr Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø
title_full_unstemmed Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø
title_short Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø
title_sort supplementation with high doses of vitamin d to subjects without vitamin d deficiency may have negative effects: pooled data from four intervention trials in tromsø
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612485/
https://www.ncbi.nlm.nih.gov/pubmed/23577264
http://dx.doi.org/10.1155/2013/348705
work_keys_str_mv AT jorderolf supplementationwithhighdosesofvitamindtosubjectswithoutvitaminddeficiencymayhavenegativeeffectspooleddatafromfourinterventiontrialsintromsø
AT strandhutchinsonmoira supplementationwithhighdosesofvitamindtosubjectswithoutvitaminddeficiencymayhavenegativeeffectspooleddatafromfourinterventiontrialsintromsø
AT kjærgaardmarie supplementationwithhighdosesofvitamindtosubjectswithoutvitaminddeficiencymayhavenegativeeffectspooleddatafromfourinterventiontrialsintromsø
AT snevemonica supplementationwithhighdosesofvitamindtosubjectswithoutvitaminddeficiencymayhavenegativeeffectspooleddatafromfourinterventiontrialsintromsø
AT grimnesguri supplementationwithhighdosesofvitamindtosubjectswithoutvitaminddeficiencymayhavenegativeeffectspooleddatafromfourinterventiontrialsintromsø