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Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study

AIMS: Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically relevant genetic variation in their efficacy. This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess...

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Detalles Bibliográficos
Autores principales:	Hopewell, Jemma C., Parish, Sarah, Offer, Alison, Link, Emma, Clarke, Robert, Lathrop, Mark, Armitage, Jane, Collins, Rory
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612775/ https://www.ncbi.nlm.nih.gov/pubmed/23100282 http://dx.doi.org/10.1093/eurheartj/ehs344

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