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Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study

OBJECTIVE: The purpose of this study is to investigate the usefulness of sympathetic skin response (SSR) and heart rate variability (HRV) for the differential diagnosis of patients with dementia with Lewy bodies (DLB). DESIGN: A diagnostic test study. SETTING: Single centre in Japan. PARTICIPANTS: W...

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Autores principales: Negami, Masako, Maruta, Takahiro, Takeda, Chie, Adachi, Yumi, Yoshikawa, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612799/
https://www.ncbi.nlm.nih.gov/pubmed/23457321
http://dx.doi.org/10.1136/bmjopen-2012-001796
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author Negami, Masako
Maruta, Takahiro
Takeda, Chie
Adachi, Yumi
Yoshikawa, Hiroaki
author_facet Negami, Masako
Maruta, Takahiro
Takeda, Chie
Adachi, Yumi
Yoshikawa, Hiroaki
author_sort Negami, Masako
collection PubMed
description OBJECTIVE: The purpose of this study is to investigate the usefulness of sympathetic skin response (SSR) and heart rate variability (HRV) for the differential diagnosis of patients with dementia with Lewy bodies (DLB). DESIGN: A diagnostic test study. SETTING: Single centre in Japan. PARTICIPANTS: We examined 20 patients with probable Alzheimer's disease (AD) diagnosed with NINCDS-ADRDA criteria and 20 with probable DLB diagnosed with the criteria of the third international DLB workshop. METHODS: For the SSR measurement, surface electrodes were used: the active recording electrode was placed on the palm of the hand and the reference electrode was placed on the dorsum of the same hand. SSR was induced by a median nerve electrical stimulation at an amplitude of 20 mA. For the HRV measurement, the A–A intervals were measured twice for 2 min with an interval of 5 min in a sitting position after a rest of 5 min. From the low-frequency power (LF; 0.02–0.15 Hz) and high-frequency power (HF; 0.15–0.50 Hz), the ratio of LF to HF power (LF/HF) was calculated using the maximal entropy method. RESULTS: SSR and HRV could detect the abnormality of autonomic function in patients with DLB at sensitivities of 85% and 90%, respectively. On the other hand, SSR and HRV detected an abnormality of autonomic function in patients with AD at sensitivities of 15% and 25% (p<0.05). The combination of the SSR and the HRV (double-positive) indicated abnormal autonomic function was recorded in only 1 of 20 patients (5%) with AD. In contrast, this combination indicated autonomic abnormality in 15 of 20 patients with DLB by our criteria (75%). CONCLUSIONS: SSR and HRV can be applied to differentiate DLB from AD.
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spelling pubmed-36127992013-07-08 Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study Negami, Masako Maruta, Takahiro Takeda, Chie Adachi, Yumi Yoshikawa, Hiroaki BMJ Open Neurology OBJECTIVE: The purpose of this study is to investigate the usefulness of sympathetic skin response (SSR) and heart rate variability (HRV) for the differential diagnosis of patients with dementia with Lewy bodies (DLB). DESIGN: A diagnostic test study. SETTING: Single centre in Japan. PARTICIPANTS: We examined 20 patients with probable Alzheimer's disease (AD) diagnosed with NINCDS-ADRDA criteria and 20 with probable DLB diagnosed with the criteria of the third international DLB workshop. METHODS: For the SSR measurement, surface electrodes were used: the active recording electrode was placed on the palm of the hand and the reference electrode was placed on the dorsum of the same hand. SSR was induced by a median nerve electrical stimulation at an amplitude of 20 mA. For the HRV measurement, the A–A intervals were measured twice for 2 min with an interval of 5 min in a sitting position after a rest of 5 min. From the low-frequency power (LF; 0.02–0.15 Hz) and high-frequency power (HF; 0.15–0.50 Hz), the ratio of LF to HF power (LF/HF) was calculated using the maximal entropy method. RESULTS: SSR and HRV could detect the abnormality of autonomic function in patients with DLB at sensitivities of 85% and 90%, respectively. On the other hand, SSR and HRV detected an abnormality of autonomic function in patients with AD at sensitivities of 15% and 25% (p<0.05). The combination of the SSR and the HRV (double-positive) indicated abnormal autonomic function was recorded in only 1 of 20 patients (5%) with AD. In contrast, this combination indicated autonomic abnormality in 15 of 20 patients with DLB by our criteria (75%). CONCLUSIONS: SSR and HRV can be applied to differentiate DLB from AD. BMJ Publishing Group 2013-03-01 /pmc/articles/PMC3612799/ /pubmed/23457321 http://dx.doi.org/10.1136/bmjopen-2012-001796 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions this is an open-access article distributed under the terms of the creative commons attribution non-commercial license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. see: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Neurology
Negami, Masako
Maruta, Takahiro
Takeda, Chie
Adachi, Yumi
Yoshikawa, Hiroaki
Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study
title Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study
title_full Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study
title_fullStr Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study
title_full_unstemmed Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study
title_short Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer's disease: a diagnostic test study
title_sort sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of lewy body dementia and alzheimer's disease: a diagnostic test study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612799/
https://www.ncbi.nlm.nih.gov/pubmed/23457321
http://dx.doi.org/10.1136/bmjopen-2012-001796
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