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Use of Transgenic Animals in Biotechnology: Prospects and Problems

During the past two decades, there have been numerous attempts at using animals in order to produce recombinant human proteins and monoclonal antibodies. However, it is only recently that the first two therapeutic agents isolated from the milk of transgenic animals, C1 inhibitor (Ruconest) and antit...

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Autores principales: Maksimenko, O. G., Deykin, A.V., Khodarovich, Yu. M., Georgiev, P. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612824/
https://www.ncbi.nlm.nih.gov/pubmed/23556129
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author Maksimenko, O. G.
Deykin, A.V.
Khodarovich, Yu. M.
Georgiev, P. G.
author_facet Maksimenko, O. G.
Deykin, A.V.
Khodarovich, Yu. M.
Georgiev, P. G.
author_sort Maksimenko, O. G.
collection PubMed
description During the past two decades, there have been numerous attempts at using animals in order to produce recombinant human proteins and monoclonal antibodies. However, it is only recently that the first two therapeutic agents isolated from the milk of transgenic animals, C1 inhibitor (Ruconest) and antithrombin (ATryn), appeared on the market. This inspires hope that a considerable number of new recombinant proteins created using such technology could become available for practical use in the near future. In this review, the methods applied to produce transgenic animals are described and the advantages and drawbacks related to their use for producing recombinant human proteins and monoclonal antibodies are discussed.
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spelling pubmed-36128242013-04-03 Use of Transgenic Animals in Biotechnology: Prospects and Problems Maksimenko, O. G. Deykin, A.V. Khodarovich, Yu. M. Georgiev, P. G. Acta Naturae Research Article During the past two decades, there have been numerous attempts at using animals in order to produce recombinant human proteins and monoclonal antibodies. However, it is only recently that the first two therapeutic agents isolated from the milk of transgenic animals, C1 inhibitor (Ruconest) and antithrombin (ATryn), appeared on the market. This inspires hope that a considerable number of new recombinant proteins created using such technology could become available for practical use in the near future. In this review, the methods applied to produce transgenic animals are described and the advantages and drawbacks related to their use for producing recombinant human proteins and monoclonal antibodies are discussed. A.I. Gordeyev 2013 /pmc/articles/PMC3612824/ /pubmed/23556129 Text en Copyright © 2013 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Maksimenko, O. G.
Deykin, A.V.
Khodarovich, Yu. M.
Georgiev, P. G.
Use of Transgenic Animals in Biotechnology: Prospects and Problems
title Use of Transgenic Animals in Biotechnology: Prospects and Problems
title_full Use of Transgenic Animals in Biotechnology: Prospects and Problems
title_fullStr Use of Transgenic Animals in Biotechnology: Prospects and Problems
title_full_unstemmed Use of Transgenic Animals in Biotechnology: Prospects and Problems
title_short Use of Transgenic Animals in Biotechnology: Prospects and Problems
title_sort use of transgenic animals in biotechnology: prospects and problems
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612824/
https://www.ncbi.nlm.nih.gov/pubmed/23556129
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