Cargando…
Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613054/ https://www.ncbi.nlm.nih.gov/pubmed/23586020 http://dx.doi.org/10.1155/2013/202905 |
_version_ | 1782264703734513664 |
---|---|
author | Zhong, Yisheng Wang, Jing Luo, Xunda |
author_facet | Zhong, Yisheng Wang, Jing Luo, Xunda |
author_sort | Zhong, Yisheng |
collection | PubMed |
description | Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro and in vivo data strongly indicate that integrin-mediated signaling events can modulate the organization of the actin cytoskeleton in trabecular meshwork (TM) cells and are associated with astrocyte migration and microglia activation of the optic nerve head in patients with primary open angle glaucoma. Consequently, increase in resistance in the TM outflow pathways and remodeling of the optic nerve head occur, which in turn increases intraocular pressure (IOP), adds additional mechanical stress and strain to optic nerve axons, and accelerates damage of axons initially caused by optic nerve head remodeling. Integrins appear to be ideal candidates for translating physical stress and strain into cellular responses known to occur in glaucomatous optic neuropathy. |
format | Online Article Text |
id | pubmed-3613054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36130542013-04-12 Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma Zhong, Yisheng Wang, Jing Luo, Xunda Biomed Res Int Review Article Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro and in vivo data strongly indicate that integrin-mediated signaling events can modulate the organization of the actin cytoskeleton in trabecular meshwork (TM) cells and are associated with astrocyte migration and microglia activation of the optic nerve head in patients with primary open angle glaucoma. Consequently, increase in resistance in the TM outflow pathways and remodeling of the optic nerve head occur, which in turn increases intraocular pressure (IOP), adds additional mechanical stress and strain to optic nerve axons, and accelerates damage of axons initially caused by optic nerve head remodeling. Integrins appear to be ideal candidates for translating physical stress and strain into cellular responses known to occur in glaucomatous optic neuropathy. Hindawi Publishing Corporation 2013 2013-03-18 /pmc/articles/PMC3613054/ /pubmed/23586020 http://dx.doi.org/10.1155/2013/202905 Text en Copyright © 2013 Yisheng Zhong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhong, Yisheng Wang, Jing Luo, Xunda Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma |
title | Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma |
title_full | Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma |
title_fullStr | Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma |
title_full_unstemmed | Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma |
title_short | Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma |
title_sort | integrins in trabecular meshwork and optic nerve head: possible association with the pathogenesis of glaucoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613054/ https://www.ncbi.nlm.nih.gov/pubmed/23586020 http://dx.doi.org/10.1155/2013/202905 |
work_keys_str_mv | AT zhongyisheng integrinsintrabecularmeshworkandopticnerveheadpossibleassociationwiththepathogenesisofglaucoma AT wangjing integrinsintrabecularmeshworkandopticnerveheadpossibleassociationwiththepathogenesisofglaucoma AT luoxunda integrinsintrabecularmeshworkandopticnerveheadpossibleassociationwiththepathogenesisofglaucoma |