Cargando…

Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma

Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Yisheng, Wang, Jing, Luo, Xunda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613054/
https://www.ncbi.nlm.nih.gov/pubmed/23586020
http://dx.doi.org/10.1155/2013/202905
_version_ 1782264703734513664
author Zhong, Yisheng
Wang, Jing
Luo, Xunda
author_facet Zhong, Yisheng
Wang, Jing
Luo, Xunda
author_sort Zhong, Yisheng
collection PubMed
description Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro and in vivo data strongly indicate that integrin-mediated signaling events can modulate the organization of the actin cytoskeleton in trabecular meshwork (TM) cells and are associated with astrocyte migration and microglia activation of the optic nerve head in patients with primary open angle glaucoma. Consequently, increase in resistance in the TM outflow pathways and remodeling of the optic nerve head occur, which in turn increases intraocular pressure (IOP), adds additional mechanical stress and strain to optic nerve axons, and accelerates damage of axons initially caused by optic nerve head remodeling. Integrins appear to be ideal candidates for translating physical stress and strain into cellular responses known to occur in glaucomatous optic neuropathy.
format Online
Article
Text
id pubmed-3613054
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36130542013-04-12 Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma Zhong, Yisheng Wang, Jing Luo, Xunda Biomed Res Int Review Article Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro and in vivo data strongly indicate that integrin-mediated signaling events can modulate the organization of the actin cytoskeleton in trabecular meshwork (TM) cells and are associated with astrocyte migration and microglia activation of the optic nerve head in patients with primary open angle glaucoma. Consequently, increase in resistance in the TM outflow pathways and remodeling of the optic nerve head occur, which in turn increases intraocular pressure (IOP), adds additional mechanical stress and strain to optic nerve axons, and accelerates damage of axons initially caused by optic nerve head remodeling. Integrins appear to be ideal candidates for translating physical stress and strain into cellular responses known to occur in glaucomatous optic neuropathy. Hindawi Publishing Corporation 2013 2013-03-18 /pmc/articles/PMC3613054/ /pubmed/23586020 http://dx.doi.org/10.1155/2013/202905 Text en Copyright © 2013 Yisheng Zhong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhong, Yisheng
Wang, Jing
Luo, Xunda
Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
title Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
title_full Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
title_fullStr Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
title_full_unstemmed Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
title_short Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
title_sort integrins in trabecular meshwork and optic nerve head: possible association with the pathogenesis of glaucoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613054/
https://www.ncbi.nlm.nih.gov/pubmed/23586020
http://dx.doi.org/10.1155/2013/202905
work_keys_str_mv AT zhongyisheng integrinsintrabecularmeshworkandopticnerveheadpossibleassociationwiththepathogenesisofglaucoma
AT wangjing integrinsintrabecularmeshworkandopticnerveheadpossibleassociationwiththepathogenesisofglaucoma
AT luoxunda integrinsintrabecularmeshworkandopticnerveheadpossibleassociationwiththepathogenesisofglaucoma