Cargando…

Colloidal Aggregation Causes Inhibition of G Protein-Coupled Receptors

[Image: see text] Colloidal aggregation is the dominant mechanism for artifactual inhibition of soluble proteins, and controls against it are now widely deployed. Conversely, investigating this mechanism for membrane-bound receptors has proven difficult. Here we investigate the activity of four well...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sassano, Maria F., Doak, Allison K., Roth, Bryan L., Shoichet, Brian K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613083/ https://www.ncbi.nlm.nih.gov/pubmed/23437772 http://dx.doi.org/10.1021/jm301749y

Ejemplares similares

A Pharmacological Organization of G Protein-coupled Receptors
por: Lin, Henry, et al.
Publicado: (2013)

Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture
por: Owen, Shawn C., et al.
Publicado: (2012)

Colloid Formation by Drugs in Simulated Intestinal Fluid
por: Doak, Allison K., et al.
Publicado: (2010)

Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor
por: Weiss, Dahlia R., et al.
Publicado: (2013)

Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves
por: Owen, Shawn C., et al.
Publicado: (2014)

Synthetic Ionizable Colloidal Drug Aggregates Enable Endosomal Disruption
por: Donders, Eric N., et al.
Publicado: (2023)

Colloidal aggregation confounds cell-based Covid-19 antiviral screens
por: Glenn, Isabella S., et al.
Publicado: (2023)

Agonist and antagonist TRUPATH assays for G protein-coupled receptors
por: DiBerto, Jeffrey F., et al.
Publicado: (2022)

Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets
por: Weiss, Dahlia R., et al.
Publicado: (2018)

Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors
por: Nichols, Charles D., et al.
Publicado: (2009)

Suspensions of colloidal particles and aggregates
por: Babick, Frank
Publicado: (2016)

G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis
por: Billard, Matthew J., et al.
Publicado: (2016)

Applications of molecular replacement to G protein-coupled receptors
por: Kruse, Andrew C., et al.
Publicado: (2013)

STRUCTURE OF THE D(2) DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE
por: Wang, Sheng, et al.
Publicado: (2018)

G protein-coupled receptors /
Publicado: (2000)

G-Protein-Coupled Receptors
por: Thiriet, Marc
Publicado: (2011)

The G-Protein–Coupled Estrogen Receptor Agonist G-1 Inhibits Proliferation and Causes Apoptosis in Leukemia Cell Lines of T Lineage
por: Torres-López, Liliana, et al.
Publicado: (2022)

Peptide ligand recognition by G protein-coupled receptors
por: Krumm, Brian E., et al.
Publicado: (2015)

In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding
por: Lemieux, George A., et al.
Publicado: (2013)

A G-Protein Coupled Receptor and Macular Degeneration
por: Figueroa, Anna G., et al.
Publicado: (2020)

Structure Based Descriptors for the Estimation of Colloidal Interactions and Protein Aggregation Propensities
por: Brunsteiner, Michael, et al.
Publicado: (2013)

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
por: Chan, John D., et al.
Publicado: (2017)

Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma
por: Natale, Christopher A., et al.
Publicado: (2020)

Rigidity-Induced Controlled Aggregation of Binary Colloids
por: Shireen, Zakiya, et al.
Publicado: (2023)

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
por: Foster, Simon R., et al.
Publicado: (2019)

GPCRdb: the G protein‐coupled receptor database – an introduction
por: Munk, C, et al.
Publicado: (2016)

G Protein-Coupled Receptors in Cancer
por: Bar-Shavit, Rachel, et al.
Publicado: (2016)

G-protein-coupled Receptors in Fungi
por: El-Defrawy, Mohamed M. H., et al.
Publicado: (2020)

G Protein-Coupled Receptors in Osteoarthritis
por: Wang, Fanhua, et al.
Publicado: (2022)

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding
por: Coan, Kristin E. D., et al.
Publicado: (2009)

Estrogen and G protein-coupled estrogen receptor agonist G-1 cause relaxation of human gallbladder
por: Lee, Ming-Che, et al.
Publicado: (2016)

Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases
por: Homan, Kristoff T., et al.
Publicado: (2014)

Predicting the Coupling Specificity of G-protein Coupled Receptors to G-proteins by Support Vector Machines
por: Guan, Cui-Ping, et al.
Publicado: (2005)

Hydration-mediated G-protein–coupled receptor activation
por: Fried, Steven D. E., et al.
Publicado: (2022)

PRECOG: PREdicting COupling probabilities of G-protein coupled receptors
por: Singh, Gurdeep, et al.
Publicado: (2019)

Dynamics of colloidal aggregation in microgravity by critical Casimir forces
por: Potenza, M.A.C., et al.
Publicado: (2014)

Does Shining Light on Gold Colloids Influence Aggregation?
por: Bhattacharya, Susmita, et al.
Publicado: (2014)

Aggregation behavior of nanoparticles: Revisiting the phase diagram of colloids
por: Bini, Margherita, et al.
Publicado: (2022)

Visualization of arrestin recruitment by a G Protein-Coupled Receptor
por: Shukla, Arun K., et al.
Publicado: (2014)

The G protein-coupled receptor identity of the frizzled proteins
por: Katanaev, VL, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_q1km4k9ksoo8jantna0enn1qrr