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Obesity and Metabolic Comorbidities: Environmental Diseases?
Obesity and metabolic comorbidities represent increasing health problems. Endocrine disrupting compounds (EDCs) are exogenous agents that change endocrine function and cause adverse health effects. Most EDCs are synthetic chemicals; some are natural food components as phytoestrogens. People are expo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613100/ https://www.ncbi.nlm.nih.gov/pubmed/23577225 http://dx.doi.org/10.1155/2013/640673 |
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author | Lubrano, Carla Genovesi, Giuseppe Specchia, Palma Costantini, Daniela Mariani, Stefania Petrangeli, Elisa Lenzi, Andrea Gnessi, Lucio |
author_facet | Lubrano, Carla Genovesi, Giuseppe Specchia, Palma Costantini, Daniela Mariani, Stefania Petrangeli, Elisa Lenzi, Andrea Gnessi, Lucio |
author_sort | Lubrano, Carla |
collection | PubMed |
description | Obesity and metabolic comorbidities represent increasing health problems. Endocrine disrupting compounds (EDCs) are exogenous agents that change endocrine function and cause adverse health effects. Most EDCs are synthetic chemicals; some are natural food components as phytoestrogens. People are exposed to complex mixtures of chemicals throughout their lives. EDCs impact hormone-dependent metabolic systems and brain function. Laboratory and human studies provide compelling evidence that human chemical contamination can play a role in obesity epidemic. Chemical exposures may increase the risk of obesity by altering the differentiation of adipocytes. EDCs can alter methylation patterns and normal epigenetic programming in cells. Oxidative stress may be induced by many of these chemicals, and accumulating evidence indicates that it plays important roles in the etiology of chronic diseases. The individual sensitivity to chemicals is variable, depending on environment and ability to metabolize hazardous chemicals. A number of genes, especially those representing antioxidant and detoxification pathways, have potential application as biomarkers of risk assessment. The potential health effects of combined exposures make the risk assessment process more complex compared to the assessment of single chemicals. Techniques and methods need to be further developed to fill data gaps and increase the knowledge on harmful exposure combinations. |
format | Online Article Text |
id | pubmed-3613100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36131002013-04-10 Obesity and Metabolic Comorbidities: Environmental Diseases? Lubrano, Carla Genovesi, Giuseppe Specchia, Palma Costantini, Daniela Mariani, Stefania Petrangeli, Elisa Lenzi, Andrea Gnessi, Lucio Oxid Med Cell Longev Review Article Obesity and metabolic comorbidities represent increasing health problems. Endocrine disrupting compounds (EDCs) are exogenous agents that change endocrine function and cause adverse health effects. Most EDCs are synthetic chemicals; some are natural food components as phytoestrogens. People are exposed to complex mixtures of chemicals throughout their lives. EDCs impact hormone-dependent metabolic systems and brain function. Laboratory and human studies provide compelling evidence that human chemical contamination can play a role in obesity epidemic. Chemical exposures may increase the risk of obesity by altering the differentiation of adipocytes. EDCs can alter methylation patterns and normal epigenetic programming in cells. Oxidative stress may be induced by many of these chemicals, and accumulating evidence indicates that it plays important roles in the etiology of chronic diseases. The individual sensitivity to chemicals is variable, depending on environment and ability to metabolize hazardous chemicals. A number of genes, especially those representing antioxidant and detoxification pathways, have potential application as biomarkers of risk assessment. The potential health effects of combined exposures make the risk assessment process more complex compared to the assessment of single chemicals. Techniques and methods need to be further developed to fill data gaps and increase the knowledge on harmful exposure combinations. Hindawi Publishing Corporation 2013 2013-03-18 /pmc/articles/PMC3613100/ /pubmed/23577225 http://dx.doi.org/10.1155/2013/640673 Text en Copyright © 2013 Carla Lubrano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lubrano, Carla Genovesi, Giuseppe Specchia, Palma Costantini, Daniela Mariani, Stefania Petrangeli, Elisa Lenzi, Andrea Gnessi, Lucio Obesity and Metabolic Comorbidities: Environmental Diseases? |
title | Obesity and Metabolic Comorbidities: Environmental Diseases? |
title_full | Obesity and Metabolic Comorbidities: Environmental Diseases? |
title_fullStr | Obesity and Metabolic Comorbidities: Environmental Diseases? |
title_full_unstemmed | Obesity and Metabolic Comorbidities: Environmental Diseases? |
title_short | Obesity and Metabolic Comorbidities: Environmental Diseases? |
title_sort | obesity and metabolic comorbidities: environmental diseases? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613100/ https://www.ncbi.nlm.nih.gov/pubmed/23577225 http://dx.doi.org/10.1155/2013/640673 |
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