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Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study

Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the r...

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Autores principales: Osterne, Rafael L., Araújo, Phelype M., de Souza-Carvalho, Abrahao C., Cavalcante, Roberta B., Sant’Ana, Eduardo, Nongueira, Renato L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613330/
https://www.ncbi.nlm.nih.gov/pubmed/23385503
http://dx.doi.org/10.4317/medoral.18345
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author Osterne, Rafael L.
Araújo, Phelype M.
de Souza-Carvalho, Abrahao C.
Cavalcante, Roberta B.
Sant’Ana, Eduardo
Nongueira, Renato L.
author_facet Osterne, Rafael L.
Araújo, Phelype M.
de Souza-Carvalho, Abrahao C.
Cavalcante, Roberta B.
Sant’Ana, Eduardo
Nongueira, Renato L.
author_sort Osterne, Rafael L.
collection PubMed
description Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the results. Results: Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Considering the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections. Conclusion: In view of the results analyzed, intralesional corticosteroid injections could be considered as first treatment option for central giant cell lesion. Key words:Central giant cell lesion, corticosteroids injections, triamcinolone hexacetonide, triamcinolone acetonide.
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spelling pubmed-36133302013-04-02 Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study Osterne, Rafael L. Araújo, Phelype M. de Souza-Carvalho, Abrahao C. Cavalcante, Roberta B. Sant’Ana, Eduardo Nongueira, Renato L. Med Oral Patol Oral Cir Bucal Review-Article Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the results. Results: Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Considering the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections. Conclusion: In view of the results analyzed, intralesional corticosteroid injections could be considered as first treatment option for central giant cell lesion. Key words:Central giant cell lesion, corticosteroids injections, triamcinolone hexacetonide, triamcinolone acetonide. Medicina Oral S.L. 2013-03 2013-02-05 /pmc/articles/PMC3613330/ /pubmed/23385503 http://dx.doi.org/10.4317/medoral.18345 Text en Copyright: © 2013 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review-Article
Osterne, Rafael L.
Araújo, Phelype M.
de Souza-Carvalho, Abrahao C.
Cavalcante, Roberta B.
Sant’Ana, Eduardo
Nongueira, Renato L.
Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study
title Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study
title_full Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study
title_fullStr Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study
title_full_unstemmed Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study
title_short Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: A meta-analytic study
title_sort intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: a meta-analytic study
topic Review-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613330/
https://www.ncbi.nlm.nih.gov/pubmed/23385503
http://dx.doi.org/10.4317/medoral.18345
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