Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function

Expression of A53T mutant human alpha-synuclein under the mouse prion promoter is among the most successful transgenic models of Parkinson's disease. Accumulation of A53T alpha-synuclein causes adult mice to develop severe motor impairment resulting in early death at 8–12 months of age. In youn...

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Detalles Bibliográficos
Autores principales: Oaks, Adam W., Frankfurt, Maya, Finkelstein, David I., Sidhu, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613356/
https://www.ncbi.nlm.nih.gov/pubmed/23560093
http://dx.doi.org/10.1371/journal.pone.0060378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613356/
https://www.ncbi.nlm.nih.gov/pubmed/23560093
http://dx.doi.org/10.1371/journal.pone.0060378

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