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Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function
Expression of A53T mutant human alpha-synuclein under the mouse prion promoter is among the most successful transgenic models of Parkinson's disease. Accumulation of A53T alpha-synuclein causes adult mice to develop severe motor impairment resulting in early death at 8–12 months of age. In youn...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613356/ https://www.ncbi.nlm.nih.gov/pubmed/23560093 http://dx.doi.org/10.1371/journal.pone.0060378 |