Enhancing Specific-Antibody Production to the ragB Vaccine with GITRL That Expand Tfh, IFN-γ(+) T Cells and Attenuates Porphyromonas gingivalis Infection in Mice

The outer membrane protein RagB is one of the major virulence factors of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis). In order to induce protective immune response against P. gingivalis infection, an mGITRL gene-linked ragB DNA vaccine (pIRES-ragB-mGITRL ) was constructed. Six-...

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Detalles Bibliográficos
Autores principales: Zheng, Dong, Sun, Qiang, Su, Zhaoliang, Kong, Fanzhi, Shi, Xiaoju, Tong, Jia, Shen, Pei, Peng, Tianqing, Wang, Shengjun, Xu, Huaxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613392/
https://www.ncbi.nlm.nih.gov/pubmed/23560053
http://dx.doi.org/10.1371/journal.pone.0059604

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