Cargando…

Remodeling of Oxidative Energy Metabolism by Galactose Improves Glucose Handling and Metabolic Switching in Human Skeletal Muscle Cells

Cultured human myotubes have a low mitochondrial oxidative potential. This study aims to remodel energy metabolism in myotubes by replacing glucose with galactose during growth and differentiation to ultimately examine the consequences for fatty acid and glucose metabolism. Exposure to galactose sho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kase, Eili Tranheim, Nikolić, Nataša, Bakke, Siril Skaret, Bogen, Kaja Kamilla, Aas, Vigdis, Thoresen, G. Hege, Rustan, Arild Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613401/ https://www.ncbi.nlm.nih.gov/pubmed/23560061 http://dx.doi.org/10.1371/journal.pone.0059972

Ejemplares similares

Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise
por: Nikolić, Nataša, et al.
Publicado: (2012)

Correction: Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise
por: Nikolić, Nataša, et al.
Publicado: (2013)

Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome
por: Mengeste, Abel M., et al.
Publicado: (2022)

Development of three-dimensional primary human myospheres as culture model of skeletal muscle cells for metabolic studies
por: Dalmao-Fernandez, Andrea, et al.
Publicado: (2023)

Energy metabolism in skeletal muscle cells from donors with different body mass index
por: Katare, Parmeshwar B., et al.
Publicado: (2022)

Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid
por: Løvsletten, Nils G., et al.
Publicado: (2018)

Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects
por: Bakke, Siril S., et al.
Publicado: (2015)

Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver
por: Kong, Xiang Yi, et al.
Publicado: (2015)

The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells
por: Mengeste, Abel M., et al.
Publicado: (2021)

Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes
por: Skagen, Christine, et al.
Publicado: (2021)

Substrate oxidation in primary human skeletal muscle cells is influenced by donor age
por: Aas, Vigdis, et al.
Publicado: (2020)

Knockdown of sarcolipin (SLN) impairs substrate utilization in human skeletal muscle cells
por: Mengeste, Abel M., et al.
Publicado: (2022)

Pancreatic Cancer Cell-Conditioned, Human-Derived Primary Myotubes Display Increased Leucine Turnover, Increased Lipid Accumulation, and Reduced Glucose Uptake
por: Krapf, Solveig A., et al.
Publicado: (2022)

The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells
por: Tingstad, Ragna H., et al.
Publicado: (2021)

Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism
por: Løvsletten, Nils G., et al.
Publicado: (2020)

Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes
por: Lund, Jenny, et al.
Publicado: (2019)

SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells
por: Lund, Jenny, et al.
Publicado: (2021)

Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes
por: Sparks, Lauren M., et al.
Publicado: (2011)

Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells
por: Nikolić, Nataša, et al.
Publicado: (2012)

Erratum to “Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells”
por: Nikolić, Nataša, et al.
Publicado: (2013)

Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects
por: Lund, Jenny, et al.
Publicado: (2018)

A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
por: Lindquist, Carine, et al.
Publicado: (2019)

Simvastatin Inhibits Glucose Metabolism and Legumain Activity in Human Myotubes
por: Smith, Robert, et al.
Publicado: (2014)

Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism
por: Lund, Jenny, et al.
Publicado: (2018)

The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling
por: Sharpe, Martyn A., et al.
Publicado: (2021)

Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism
por: Lund, Jenny, et al.
Publicado: (2017)

Effect of differentiation, de novo innervation, and electrical pulse stimulation on mRNA and protein expression of Na(+),K(+)-ATPase, FXYD1, and FXYD5 in cultured human skeletal muscle cells
por: Jan, Vid, et al.
Publicado: (2021)

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
por: Kong, Xiang Y., et al.
Publicado: (2014)

Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells
por: Ho, Giang Thanh Thi, et al.
Publicado: (2017)

Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism
por: Lunde, Ngoc Nguyen, et al.
Publicado: (2023)

Transcriptional Profiling of Myceliophthora thermophila on Galactose and Metabolic Engineering for Improved Galactose Utilization
por: Wang, Hanyu, et al.
Publicado: (2021)

Enhanced Glucose Uptake in Human Liver Cells and Inhibition of Carbohydrate Hydrolyzing Enzymes by Nordic Berry Extracts
por: Ho, Giang Thanh Thi, et al.
Publicado: (2017)

Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells
por: Krajčová, Adéla, et al.
Publicado: (2022)

Editorial: Untangling energy metabolism in skeletal muscle: From physiology to pharmacology
por: Pirkmajer, Sergej, et al.
Publicado: (2022)

METABOLIC INTERMEDIATES IN ADAPTIVE FERMENTATION OF GALACTOSE BY YEAST
por: Reiner, John M.
Publicado: (1947)

Engineering CHO cell metabolism for growth in galactose
por: Jiménez, Natalia E, et al.
Publicado: (2011)

Fluorinated Galactoses Inhibit Galactose-1-Phosphate Uridyltransferase and Metabolically Induce Galactosemia-like Phenotypes in HEK-293 Cells
por: Janes, Verena, et al.
Publicado: (2020)

Influence of galactose cataract on erythrocytic and lenticular glutathione metabolism in albino rats
por: Jyothi, M, et al.
Publicado: (2011)

l-Galactose Metabolism in Bacteroides vulgatus from the Human Gut Microbiota
por: Hobbs, Merlin Eric, et al.
Publicado: (2014)

Flux-Enabled Exploration of the Role of Sip1 in Galactose Yeast Metabolism
por: Shymansky, Christopher M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c01rbo682hdqmavp8t2lbeai6c