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Tacrolimus Inhibits NF-κB Activation in Peripheral Human T Cells

The calcineurin inhibitor, tacrolimus (TAC), inhibits the protein phosphatase activity of calcineurin, leading to suppression of the nuclear translocation of NFAT and inhibition of T cell activation. Apart from NFAT also the transcription factor NF-κB plays a key functional role in T cell activation...

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Detalles Bibliográficos
Autores principales:	Vafadari, Ramin, Kraaijeveld, Rens, Weimar, Willem, Baan, Carla C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613409/ https://www.ncbi.nlm.nih.gov/pubmed/23573283 http://dx.doi.org/10.1371/journal.pone.0060784

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