Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion

OBJECTIVES: Data on the optimal head position for patients with acute ischemic stroke are unavailable. We evaluated the effects of mild head-down tilt (HDT) on cerebral blood flow (CBF) in mice during bilateral common carotid artery occlusion (BCCAO). MATERIALS AND METHODS: We used mice with BCCAO (...

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Detalles Bibliográficos
Autores principales: Nagatani, Kimihiro, Nawashiro, Hiroshi, Takeuchi, Satoru, Otani, Naoki, Wada, Kojiro, Shima, Katsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613638/
https://www.ncbi.nlm.nih.gov/pubmed/23559983
http://dx.doi.org/10.4103/1793-5482.106648
Descripción
Sumario:OBJECTIVES: Data on the optimal head position for patients with acute ischemic stroke are unavailable. We evaluated the effects of mild head-down tilt (HDT) on cerebral blood flow (CBF) in mice during bilateral common carotid artery occlusion (BCCAO). MATERIALS AND METHODS: We used mice with BCCAO (35 minutes) and divided these into 2 groups ( n=16): BCCAO at 0°-HDT and 5°-HDT. CBF was measured for both hemispheres with a non-invasive laser Doppler blood perfusion imager. Changes in CBF during BCCAO were examined in both groups. RESULTS: A significantly greater increase in CBF in both hemispheres was observed in 5°-HDT mice than in 0°-HDT mice (126.1% (8.715)% vs. 102.1% (4.718)%; P=0.0294). CONCLUSION: HDT enhanced the increase in CBF in both hemispheres in the mouse BCCAO model. The potential mechanism underlying CBF increase enhanced by HDT during BCCAO warrants further investigation.

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