Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion

OBJECTIVES: Data on the optimal head position for patients with acute ischemic stroke are unavailable. We evaluated the effects of mild head-down tilt (HDT) on cerebral blood flow (CBF) in mice during bilateral common carotid artery occlusion (BCCAO). MATERIALS AND METHODS: We used mice with BCCAO (...

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Autores principales: Nagatani, Kimihiro, Nawashiro, Hiroshi, Takeuchi, Satoru, Otani, Naoki, Wada, Kojiro, Shima, Katsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613638/
https://www.ncbi.nlm.nih.gov/pubmed/23559983
http://dx.doi.org/10.4103/1793-5482.106648
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author Nagatani, Kimihiro
Nawashiro, Hiroshi
Takeuchi, Satoru
Otani, Naoki
Wada, Kojiro
Shima, Katsuji
author_facet Nagatani, Kimihiro
Nawashiro, Hiroshi
Takeuchi, Satoru
Otani, Naoki
Wada, Kojiro
Shima, Katsuji
author_sort Nagatani, Kimihiro
collection PubMed
description OBJECTIVES: Data on the optimal head position for patients with acute ischemic stroke are unavailable. We evaluated the effects of mild head-down tilt (HDT) on cerebral blood flow (CBF) in mice during bilateral common carotid artery occlusion (BCCAO). MATERIALS AND METHODS: We used mice with BCCAO (35 minutes) and divided these into 2 groups ( n=16): BCCAO at 0°-HDT and 5°-HDT. CBF was measured for both hemispheres with a non-invasive laser Doppler blood perfusion imager. Changes in CBF during BCCAO were examined in both groups. RESULTS: A significantly greater increase in CBF in both hemispheres was observed in 5°-HDT mice than in 0°-HDT mice (126.1% (8.715)% vs. 102.1% (4.718)%; P=0.0294). CONCLUSION: HDT enhanced the increase in CBF in both hemispheres in the mouse BCCAO model. The potential mechanism underlying CBF increase enhanced by HDT during BCCAO warrants further investigation.
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spelling pubmed-36136382013-04-04 Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion Nagatani, Kimihiro Nawashiro, Hiroshi Takeuchi, Satoru Otani, Naoki Wada, Kojiro Shima, Katsuji Asian J Neurosurg Original Article OBJECTIVES: Data on the optimal head position for patients with acute ischemic stroke are unavailable. We evaluated the effects of mild head-down tilt (HDT) on cerebral blood flow (CBF) in mice during bilateral common carotid artery occlusion (BCCAO). MATERIALS AND METHODS: We used mice with BCCAO (35 minutes) and divided these into 2 groups ( n=16): BCCAO at 0°-HDT and 5°-HDT. CBF was measured for both hemispheres with a non-invasive laser Doppler blood perfusion imager. Changes in CBF during BCCAO were examined in both groups. RESULTS: A significantly greater increase in CBF in both hemispheres was observed in 5°-HDT mice than in 0°-HDT mice (126.1% (8.715)% vs. 102.1% (4.718)%; P=0.0294). CONCLUSION: HDT enhanced the increase in CBF in both hemispheres in the mouse BCCAO model. The potential mechanism underlying CBF increase enhanced by HDT during BCCAO warrants further investigation. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3613638/ /pubmed/23559983 http://dx.doi.org/10.4103/1793-5482.106648 Text en Copyright: © Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nagatani, Kimihiro
Nawashiro, Hiroshi
Takeuchi, Satoru
Otani, Naoki
Wada, Kojiro
Shima, Katsuji
Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion
title Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion
title_full Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion
title_fullStr Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion
title_full_unstemmed Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion
title_short Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion
title_sort effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613638/
https://www.ncbi.nlm.nih.gov/pubmed/23559983
http://dx.doi.org/10.4103/1793-5482.106648
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