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IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria

BACKGROUND: Allergic reactions occur commonly in transfusion practice. However, severe anaphylactic reactions are rare; anti-IgA (IgA: Immunoglobulin A) in IgA-deficient patients is one of the well-illustrated and reported causes for such reactions. However, IgE-mediated hypersensitivity reaction th...

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Autores principales: Shanthi, B., Bhavanadhar, Chandran, Priscilla, Prasad, A. Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613673/
https://www.ncbi.nlm.nih.gov/pubmed/23559774
http://dx.doi.org/10.4103/0973-6247.106748
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author Shanthi, B.
Bhavanadhar,
Chandran, Priscilla
Prasad, A. Krishna
author_facet Shanthi, B.
Bhavanadhar,
Chandran, Priscilla
Prasad, A. Krishna
author_sort Shanthi, B.
collection PubMed
description BACKGROUND: Allergic reactions occur commonly in transfusion practice. However, severe anaphylactic reactions are rare; anti-IgA (IgA: Immunoglobulin A) in IgA-deficient patients is one of the well-illustrated and reported causes for such reactions. However, IgE-mediated hypersensitivity reaction through blood component transfusion may be caused in parasitic hyperimmunization for IgG and IgE antibodies. CASE REPORT: We have evaluated here a severe anaphylactic transfusion reaction retrospectively in an 18year-old male, a known case of cerebral malaria, developed after platelet transfusions. The examination and investigations revealed classical signs and symptoms of anaphylaxis along with a significant rise in the serum IgE antibody level and IgG by hemagglutination method. Initial mild allergic reaction was followed by severe anaphylactic reaction after the second transfusion of platelets. CONCLUSION: Based on these results, screening of patients and donors with mild allergic reactions to IgE antibodies may help in understanding the pathogenesis as well as in planning for preventive desensitization and measures for safe transfusion.
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spelling pubmed-36136732013-04-04 IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria Shanthi, B. Bhavanadhar, Chandran, Priscilla Prasad, A. Krishna Asian J Transfus Sci Case Report BACKGROUND: Allergic reactions occur commonly in transfusion practice. However, severe anaphylactic reactions are rare; anti-IgA (IgA: Immunoglobulin A) in IgA-deficient patients is one of the well-illustrated and reported causes for such reactions. However, IgE-mediated hypersensitivity reaction through blood component transfusion may be caused in parasitic hyperimmunization for IgG and IgE antibodies. CASE REPORT: We have evaluated here a severe anaphylactic transfusion reaction retrospectively in an 18year-old male, a known case of cerebral malaria, developed after platelet transfusions. The examination and investigations revealed classical signs and symptoms of anaphylaxis along with a significant rise in the serum IgE antibody level and IgG by hemagglutination method. Initial mild allergic reaction was followed by severe anaphylactic reaction after the second transfusion of platelets. CONCLUSION: Based on these results, screening of patients and donors with mild allergic reactions to IgE antibodies may help in understanding the pathogenesis as well as in planning for preventive desensitization and measures for safe transfusion. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3613673/ /pubmed/23559774 http://dx.doi.org/10.4103/0973-6247.106748 Text en Copyright: © Asian Journal of Transfusion Science http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shanthi, B.
Bhavanadhar,
Chandran, Priscilla
Prasad, A. Krishna
IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria
title IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria
title_full IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria
title_fullStr IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria
title_full_unstemmed IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria
title_short IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria
title_sort ige- and igg mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613673/
https://www.ncbi.nlm.nih.gov/pubmed/23559774
http://dx.doi.org/10.4103/0973-6247.106748
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