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Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model
Hypertrichosis is one of the most common side effects of systemic cyclosporine A therapy. It has been previously shown that cyclosporine A induces anagen and inhibits catagen development in mice. In the present study, to explore the mechanisms of cyclosporine A, we investigated the effects of cyclos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Department of Journal of Biomedical Research
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613734/ https://www.ncbi.nlm.nih.gov/pubmed/23554774 http://dx.doi.org/10.7555/JBR.26.20110067 |
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author | Xu, Wenrong Fan, Weixin Yao, Kun |
author_facet | Xu, Wenrong Fan, Weixin Yao, Kun |
author_sort | Xu, Wenrong |
collection | PubMed |
description | Hypertrichosis is one of the most common side effects of systemic cyclosporine A therapy. It has been previously shown that cyclosporine A induces anagen and inhibits catagen development in mice. In the present study, to explore the mechanisms of cyclosporine A, we investigated the effects of cyclosporine A on hair shaft elongation, hair follicle cell proliferation, apoptosis, and mRNA expression of selected growth factors using an organ culture model of mouse vibrissae. In this model, cyclosporine A stimulated hair growth of normal mouse vibrissae follicles by inhibiting catagen-like development and promoting matrix cell proliferation. In addition, cyclosporine A caused an increase in the expression of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and nerve growth factor (NGF), and inhibited follistatin expression. Our findings provide an explanation for the clinically observed effects of cyclosporine A on hair growth. The mouse vibrissae organ culture offers an attractive model for identifying factors involved in the modulation of hair growth. |
format | Online Article Text |
id | pubmed-3613734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Editorial Department of Journal of Biomedical Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-36137342013-04-02 Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model Xu, Wenrong Fan, Weixin Yao, Kun J Biomed Res Research Paper Hypertrichosis is one of the most common side effects of systemic cyclosporine A therapy. It has been previously shown that cyclosporine A induces anagen and inhibits catagen development in mice. In the present study, to explore the mechanisms of cyclosporine A, we investigated the effects of cyclosporine A on hair shaft elongation, hair follicle cell proliferation, apoptosis, and mRNA expression of selected growth factors using an organ culture model of mouse vibrissae. In this model, cyclosporine A stimulated hair growth of normal mouse vibrissae follicles by inhibiting catagen-like development and promoting matrix cell proliferation. In addition, cyclosporine A caused an increase in the expression of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and nerve growth factor (NGF), and inhibited follistatin expression. Our findings provide an explanation for the clinically observed effects of cyclosporine A on hair growth. The mouse vibrissae organ culture offers an attractive model for identifying factors involved in the modulation of hair growth. Editorial Department of Journal of Biomedical Research 2012-09 2012-03-29 /pmc/articles/PMC3613734/ /pubmed/23554774 http://dx.doi.org/10.7555/JBR.26.20110067 Text en © 2012 by the Journal of Biomedical Research. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Research Paper Xu, Wenrong Fan, Weixin Yao, Kun Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model |
title | Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model |
title_full | Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model |
title_fullStr | Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model |
title_full_unstemmed | Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model |
title_short | Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model |
title_sort | cyclosporine a stimulated hair growth from mouse vibrissae follicles in an organ culture model |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613734/ https://www.ncbi.nlm.nih.gov/pubmed/23554774 http://dx.doi.org/10.7555/JBR.26.20110067 |
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