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Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model

Hypertrichosis is one of the most common side effects of systemic cyclosporine A therapy. It has been previously shown that cyclosporine A induces anagen and inhibits catagen development in mice. In the present study, to explore the mechanisms of cyclosporine A, we investigated the effects of cyclos...

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Detalles Bibliográficos
Autores principales: Xu, Wenrong, Fan, Weixin, Yao, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613734/
https://www.ncbi.nlm.nih.gov/pubmed/23554774
http://dx.doi.org/10.7555/JBR.26.20110067
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author Xu, Wenrong
Fan, Weixin
Yao, Kun
author_facet Xu, Wenrong
Fan, Weixin
Yao, Kun
author_sort Xu, Wenrong
collection PubMed
description Hypertrichosis is one of the most common side effects of systemic cyclosporine A therapy. It has been previously shown that cyclosporine A induces anagen and inhibits catagen development in mice. In the present study, to explore the mechanisms of cyclosporine A, we investigated the effects of cyclosporine A on hair shaft elongation, hair follicle cell proliferation, apoptosis, and mRNA expression of selected growth factors using an organ culture model of mouse vibrissae. In this model, cyclosporine A stimulated hair growth of normal mouse vibrissae follicles by inhibiting catagen-like development and promoting matrix cell proliferation. In addition, cyclosporine A caused an increase in the expression of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and nerve growth factor (NGF), and inhibited follistatin expression. Our findings provide an explanation for the clinically observed effects of cyclosporine A on hair growth. The mouse vibrissae organ culture offers an attractive model for identifying factors involved in the modulation of hair growth.
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spelling pubmed-36137342013-04-02 Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model Xu, Wenrong Fan, Weixin Yao, Kun J Biomed Res Research Paper Hypertrichosis is one of the most common side effects of systemic cyclosporine A therapy. It has been previously shown that cyclosporine A induces anagen and inhibits catagen development in mice. In the present study, to explore the mechanisms of cyclosporine A, we investigated the effects of cyclosporine A on hair shaft elongation, hair follicle cell proliferation, apoptosis, and mRNA expression of selected growth factors using an organ culture model of mouse vibrissae. In this model, cyclosporine A stimulated hair growth of normal mouse vibrissae follicles by inhibiting catagen-like development and promoting matrix cell proliferation. In addition, cyclosporine A caused an increase in the expression of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and nerve growth factor (NGF), and inhibited follistatin expression. Our findings provide an explanation for the clinically observed effects of cyclosporine A on hair growth. The mouse vibrissae organ culture offers an attractive model for identifying factors involved in the modulation of hair growth. Editorial Department of Journal of Biomedical Research 2012-09 2012-03-29 /pmc/articles/PMC3613734/ /pubmed/23554774 http://dx.doi.org/10.7555/JBR.26.20110067 Text en © 2012 by the Journal of Biomedical Research. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Research Paper
Xu, Wenrong
Fan, Weixin
Yao, Kun
Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model
title Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model
title_full Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model
title_fullStr Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model
title_full_unstemmed Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model
title_short Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model
title_sort cyclosporine a stimulated hair growth from mouse vibrissae follicles in an organ culture model
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613734/
https://www.ncbi.nlm.nih.gov/pubmed/23554774
http://dx.doi.org/10.7555/JBR.26.20110067
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