Cargando…

CNTO 530 Increases Expression of HbA and HbF in Murine Models of β-Thalassemia and Sickle Cell Anemia

CNTO 530 is an erythropoietin receptor agonist MIMETIBODY(TM) construct. CNTO 530 has been shown to be active in a number of rodent models of acquired anemia (e.g. renal insufficiency and chemotherapy induced anemia). We investigated the efficacy of CNTO 530 in murine models of β-thalassemia and sic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Makropoulos, Dorie A, Achuthanandam, Ram, Avery, Justin, Wilson, Krista, Brosnan, Kerry, Miller, Andrew, Nesspor, Thomas, Chroscinski, Denise, Walker, Mindi, Egenolf, Devon, Huang, ChiChi, Bugelski, Peter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613800/ https://www.ncbi.nlm.nih.gov/pubmed/23157711 http://dx.doi.org/10.2174/138920113805219449

Ejemplares similares

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction
por: Zuccato, Cristina, et al.
Publicado: (2012)

Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing
por: Finotti, Alessia, et al.
Publicado: (2023)

The Effect of Alpha Thalassemia, HbF and HbC on Haematological Parameters of Sickle Cell Disease Patients in Ibadan, Nigeria
por: Fasola, Foluke Atinuke, et al.
Publicado: (2022)

Measurement of HbA(1c) and HbA(2) by Capillarys 2 Flex Piercing HbA(1c) programme for simultaneous management of diabetes and screening for thalassemia
por: Ke, Peifeng, et al.
Publicado: (2017)

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
por: Zuccato, Cristina, et al.
Publicado: (2023)

Low HbA2 Level in β-Thalassemia Trait
por: ÖZSOYLU, Şinasi
Publicado: (2013)

Effect of Cis Acting Potential Regulators in the β Globin Gene Cluster on the Production of HbF in Thalassemia Patients
por: Dabke, Pooja, et al.
Publicado: (2013)

Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes
por: Steinberg, Martin H.
Publicado: (2020)

Significance of borderline HbA(2) levels in β thalassemia carrier screening
por: Colaco, Stacy, et al.
Publicado: (2022)

Association of polymorphisms in the HBG1‐HBD intergenic region with HbF levels
por: Hu, Li, et al.
Publicado: (2020)

miRNA Expression Associated with HbF in Saudi Sickle Cell Anemia
por: Cyrus, Cyril, et al.
Publicado: (2022)

Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients
por: Cyrus, Cyril, et al.
Publicado: (2017)

Standardization of the HbA(2) Assay
por: Paleari, Renata, et al.
Publicado: (2018)

FOETAL HAEMOGLOBIN (HbF) STATUS IN ADULT SICKLE CELL ANAEMIA PATIENTS IN IBADAN, NIGERIA
por: Olaniyi, J.A., et al.
Publicado: (2010)

Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients
por: Kargutkar, Neha, et al.
Publicado: (2023)

Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF
por: Ibanez, Vinzon, et al.
Publicado: (2023)

In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene Induction by Adhatoda vasica: A Pre-Clinical Study of HbF Inducers for β-Thalassemia
por: Iftikhar, Fizza, et al.
Publicado: (2022)

Hb H Interference on Measurement Of HbA1c With Ion-Exchange HPLC
por: Agilli, Mehmet, et al.
Publicado: (2013)

Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia
por: Lebensburger, Jeffrey D, et al.
Publicado: (2015)

The compound state: Hb S/beta-thalassemia()
por: Figueiredo, Maria Stella
Publicado: (2015)

HbA(1c): The lower the better?
por: Araki, Eiichi, et al.
Publicado: (2011)

Genetic variants at HbF‐modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania
por: Mtatiro, Siana Nkya, et al.
Publicado: (2014)

The True Value of HbA1c as a Predictor of Diabetic Complications: Simulations of HbA1c Variables
por: Lind, Marcus, et al.
Publicado: (2009)

Haemoglobin J-Baltimore can be detected by HbA(1c) electropherogram but with underestimated HbA(1c) value
por: Brunel, Valéry, et al.
Publicado: (2016)

Differential Thermal Stability and Oxidative Vulnerability of the Hemoglobin Variants, HbA(2) and HbE
por: Chakrabarti, Abhijit, et al.
Publicado: (2013)

Significantly High HbA(1c) in Diabetic Patient with Hb J: Case Report
por: Wan Nik, Wan Nor Fazila Hafizan, et al.
Publicado: (2022)

Influence of Serum Albumin on HbA1c and HbA1c-Defined Glycemic Status: A Retrospective Study
por: Feng, Xiaojing, et al.
Publicado: (2021)

Association between XmnI Polymorphism and HbF Level in Sickle Cell Disease Patients from Chhattisgarh
por: Bhagat, Sanjana, et al.
Publicado: (2012)

Drugs affecting HbA1c levels
por: Unnikrishnan, Ranjit, et al.
Publicado: (2012)

Current Status of HbA1c Biosensors
por: Lin, Hua, et al.
Publicado: (2017)

Hemoglobin variants detected by hemoglobin A1c (HbA1c) analysis and the effects on HbA1c measurements
por: Nasir, Nadzimah Mohd, et al.
Publicado: (2010)

In-House Algorithm for Reporting Discrepant HbA1c Result and Troubleshooting a Case of False Low HbA1c
por: Pant, Vivek, et al.
Publicado: (2021)

Estimation of mean erythrocyte age using HbA1c or HbA1c/glycated albumin for evaluation of anemia severity
por: Koga, Masafumi, et al.
Publicado: (2023)

HbF Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines
por: Minniti, Caterina P., et al.
Publicado: (2020)

Chen J-J. HRI stress signaling and HbF production. Blood. 2020;135(24):2113-2114.
Publicado: (2020)

HbA(1c) measurement and relationship to incident stroke
por: Robson, R., et al.
Publicado: (2016)

Very low HbA1C, is it a problem?
por: Joob, Beuy, et al.
Publicado: (2018)

Engineering of the endogenous HBD promoter increases HbA2
por: Boontanrart, Mandy Y, et al.
Publicado: (2023)

Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes
por: Matsutani, Daisuke, et al.
Publicado: (2018)

Evaluation of the Effect of miR-26b Up-Regulation on HbF Expression in Erythroleukemic K-562 Cell Line
por: Alijani, Sadegh, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5d104g51i7i8rrrqalnujkdgcv