Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration

The UPR is activated in the mouse retina expressing misfolded T17M rhodopsin (RHO) during autosomal dominant retinitis pigmentosa (ADRP) progression. Therefore, the goal of this study is to validate the UPR-induced caspase-7 as a new therapeutic target that modulates the UPR, reduces the level of ap...

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Detalles Bibliográficos
Autores principales: Choudhury, S, Bhootada, Y, Gorbatyuk, O, Gorbatyuk, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613823/
https://www.ncbi.nlm.nih.gov/pubmed/23470535
http://dx.doi.org/10.1038/cddis.2013.34

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