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Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression

Nutlin-3 selectively activates p53 by inhibiting the interaction of this tumor suppressor with its negative regulator murine double minute 2 (mdm2), while trichostatin A (TSA) is one of the most potent histone deacetylase (HDAC) inhibitors currently available. As both Nutlin-3 and TSA increase the l...

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Detalles Bibliográficos
Autores principales:	Sachweh, M C C, Drummond, C J, Higgins, M, Campbell, J, Laín, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613839/ https://www.ncbi.nlm.nih.gov/pubmed/23470540 http://dx.doi.org/10.1038/cddis.2013.61

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