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Stepwise assembly of the human replicative polymerase holoenzyme

In most organisms, clamp loaders catalyze both the loading of sliding clamps onto DNA and their removal. How these opposing activities are regulated during assembly of the DNA polymerase holoenzyme remains unknown. By utilizing FRET to monitor protein-DNA interactions, we examined assembly of the hu...

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Detalles Bibliográficos
Autores principales: Hedglin, Mark, Perumal, Senthil K, Hu, Zhenxin, Benkovic, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614016/
https://www.ncbi.nlm.nih.gov/pubmed/23577232
http://dx.doi.org/10.7554/eLife.00278

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