Megaloblastic hematopoiesis in a 20 year old pregnant female

BACKGROUND: Nitrous oxide can cause disordered blood cell proliferation and lead to pancytopenia and altered immune function. CASE REPORT: A young pregnant female patient presented after binge nitrous oxide abuse with altered mental status and abnormal vital signs. From her initial assessment she wa...

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Detalles Bibliográficos
Autores principales: Trivette, Evan T., Hoedebecke, Kyle, Berry-Cabán, Cristóbal S., Jacobs, Brandy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614260/
https://www.ncbi.nlm.nih.gov/pubmed/23569553
http://dx.doi.org/10.12659/AJCR.883734
Descripción
Sumario:BACKGROUND: Nitrous oxide can cause disordered blood cell proliferation and lead to pancytopenia and altered immune function. CASE REPORT: A young pregnant female patient presented after binge nitrous oxide abuse with altered mental status and abnormal vital signs. From her initial assessment she was noted to have pancytopenia and was found to have megaloblastic, hyper-cellular changes in a subsequent bone marrow biopsy. This presentation was determined to be secondary to toxic effects after heavy use of nitrous oxide. CONCLUSIONS: Nitrous oxide exposure, including use as an inhalant, over 12 hours can lead to bone marrow abnormalities such as megaloblastic hematopoiesis.

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