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Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies
BACKGROUND: In surgical pathology, atypical small acinar proliferation is commonly detected in prostate biopsies. Most studies on atypical small acinar proliferation have examined morphological characteristics and the utility of immunohistochemical studies. However, these resources are not available...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614276/ https://www.ncbi.nlm.nih.gov/pubmed/23573463 http://dx.doi.org/10.5812/numonthly.2067 |
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author | Arista-Nasr, Julián Martínez-Mijangos, Omar Martínez-Benítez, Braulio Bornstein-Quevedo, Leticia Lino-Silva, Saul Urbina-Ramírez, Shaddaí |
author_facet | Arista-Nasr, Julián Martínez-Mijangos, Omar Martínez-Benítez, Braulio Bornstein-Quevedo, Leticia Lino-Silva, Saul Urbina-Ramírez, Shaddaí |
author_sort | Arista-Nasr, Julián |
collection | PubMed |
description | BACKGROUND: In surgical pathology, atypical small acinar proliferation is commonly detected in prostate biopsies. Most studies on atypical small acinar proliferation have examined morphological characteristics and the utility of immunohistochemical studies. However, these resources are not available to many pathology departments. We have found that examining additional sections is a simple and inexpensive method that allows better evaluation of focal prostatic glandular atypia. OBJECTIVES: The present report compares the diagnostic utility of immunohistochemical techniques versus examining additional sections in prostate biopsies with focal glandular atypia. PATIENTS AND METHODS: Thirty recently studied prostate biopsies with focal glandular atypia were selected. In each case, 3 additional levels were examined. An immunohistochemical study was performed on one level using an antibody against high-molecular-weight keratin (34BetaE12). Two additional sections were stained with hematoxylin and eosin. RESULTS: The diagnosis of focal carcinoma was established with only additional sections in 4 cases (13.3%). In 2 of these biopsies, additional areas of carcinoma were found that were not identified in the original sections. In 4 other cases, immunohistochemical analysis was the only useful method for diagnosing cancer. In 9 cases (30%), both methods were useful for classifying focal glandular atypia as carcinoma. In the remaining 13 cases,neither immunohistochemical analysis nor additional sections were useful in changing the diagnosis of focal glandular atypia. CONCLUSIONS: Focal glandular atypia in prostatic needle biopsies should be routinely examined with additional sections, particularly when immunohistochemical analysis is not possible. Some biopsies with atypical glandular proliferation may show focal carcinoma in additional sections, even if the immunohistochemical analysis did not provide a diagnosis of malignancy. Additional sections can also reveal areas of carcinoma that were not apparent in the original sections. |
format | Online Article Text |
id | pubmed-3614276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-36142762013-04-09 Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies Arista-Nasr, Julián Martínez-Mijangos, Omar Martínez-Benítez, Braulio Bornstein-Quevedo, Leticia Lino-Silva, Saul Urbina-Ramírez, Shaddaí Nephrourol Mon Original Article BACKGROUND: In surgical pathology, atypical small acinar proliferation is commonly detected in prostate biopsies. Most studies on atypical small acinar proliferation have examined morphological characteristics and the utility of immunohistochemical studies. However, these resources are not available to many pathology departments. We have found that examining additional sections is a simple and inexpensive method that allows better evaluation of focal prostatic glandular atypia. OBJECTIVES: The present report compares the diagnostic utility of immunohistochemical techniques versus examining additional sections in prostate biopsies with focal glandular atypia. PATIENTS AND METHODS: Thirty recently studied prostate biopsies with focal glandular atypia were selected. In each case, 3 additional levels were examined. An immunohistochemical study was performed on one level using an antibody against high-molecular-weight keratin (34BetaE12). Two additional sections were stained with hematoxylin and eosin. RESULTS: The diagnosis of focal carcinoma was established with only additional sections in 4 cases (13.3%). In 2 of these biopsies, additional areas of carcinoma were found that were not identified in the original sections. In 4 other cases, immunohistochemical analysis was the only useful method for diagnosing cancer. In 9 cases (30%), both methods were useful for classifying focal glandular atypia as carcinoma. In the remaining 13 cases,neither immunohistochemical analysis nor additional sections were useful in changing the diagnosis of focal glandular atypia. CONCLUSIONS: Focal glandular atypia in prostatic needle biopsies should be routinely examined with additional sections, particularly when immunohistochemical analysis is not possible. Some biopsies with atypical glandular proliferation may show focal carcinoma in additional sections, even if the immunohistochemical analysis did not provide a diagnosis of malignancy. Additional sections can also reveal areas of carcinoma that were not apparent in the original sections. Kowsar 2012-03-01 2012 /pmc/articles/PMC3614276/ /pubmed/23573463 http://dx.doi.org/10.5812/numonthly.2067 Text en Copyright © 2012 Kowsar M. P. Co. All rights reserved. http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Arista-Nasr, Julián Martínez-Mijangos, Omar Martínez-Benítez, Braulio Bornstein-Quevedo, Leticia Lino-Silva, Saul Urbina-Ramírez, Shaddaí Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies |
title | Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies |
title_full | Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies |
title_fullStr | Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies |
title_full_unstemmed | Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies |
title_short | Atypical Small Acinar Proliferation: Utility of Additional Sections and Immunohistochemical Analysis of Prostatic Needle Biopsies |
title_sort | atypical small acinar proliferation: utility of additional sections and immunohistochemical analysis of prostatic needle biopsies |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614276/ https://www.ncbi.nlm.nih.gov/pubmed/23573463 http://dx.doi.org/10.5812/numonthly.2067 |
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