Direct Renin Inhibitor: Aliskiren in Chronic Kidney Disease

The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of chronic kidney disease (CKD) progression and its increased complications such as hypertension (HT) and cardiovascular diseases (CVD). Previous studies suggested that aliskiren a direct renin inhibitor, blocks...

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Detalles Bibliográficos
Autores principales: Morishita, Yoshiyuki, Kusano, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614331/
https://www.ncbi.nlm.nih.gov/pubmed/23577328
http://dx.doi.org/10.5812/numonthly.3679
Descripción
Sumario:The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of chronic kidney disease (CKD) progression and its increased complications such as hypertension (HT) and cardiovascular diseases (CVD). Previous studies suggested that aliskiren a direct renin inhibitor, blocks RAAS and may be effective for the management of CKD and its complications. This review focuses on the effects of aliskiren on CKD.

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