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Arias-Stella reaction of the cervix: The enduring diagnostic challenge

BACKGROUND: The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia. When presenting in extra-uterine sites, the differentiati...

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Autores principales: Luks, Sophie, Simon, Rochelle A., Lawrence, W. Dwayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614382/
https://www.ncbi.nlm.nih.gov/pubmed/23569547
http://dx.doi.org/10.12659/AJCR.883584
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author Luks, Sophie
Simon, Rochelle A.
Lawrence, W. Dwayne
author_facet Luks, Sophie
Simon, Rochelle A.
Lawrence, W. Dwayne
author_sort Luks, Sophie
collection PubMed
description BACKGROUND: The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia. When presenting in extra-uterine sites, the differentiation of Arias-Stella changes from other more ominous clear cell lesions may pose significant difficulties. CASE REPORT: We report a case of an endocervical clear cell lesion incidentally discovered during a prenatal visit of a young pregnant woman. Interpretation of the pathological findings was complicated by the small size and fragmentation of the specimen. CONCLUSIONS: Recognition of Arias-Stella reaction in extra-uterine sites, especially in young women, is critical to avoid misdiagnosis of this innocuous lesion as clear cell adenocarcinoma. Attention to cellular and nuclear detail, as well as careful consideration of the clinical scenario, is crucial for establishment of the correct diagnosis.
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spelling pubmed-36143822013-04-08 Arias-Stella reaction of the cervix: The enduring diagnostic challenge Luks, Sophie Simon, Rochelle A. Lawrence, W. Dwayne Am J Case Rep Case Report BACKGROUND: The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia. When presenting in extra-uterine sites, the differentiation of Arias-Stella changes from other more ominous clear cell lesions may pose significant difficulties. CASE REPORT: We report a case of an endocervical clear cell lesion incidentally discovered during a prenatal visit of a young pregnant woman. Interpretation of the pathological findings was complicated by the small size and fragmentation of the specimen. CONCLUSIONS: Recognition of Arias-Stella reaction in extra-uterine sites, especially in young women, is critical to avoid misdiagnosis of this innocuous lesion as clear cell adenocarcinoma. Attention to cellular and nuclear detail, as well as careful consideration of the clinical scenario, is crucial for establishment of the correct diagnosis. International Scientific Literature, Inc. 2012-11-19 /pmc/articles/PMC3614382/ /pubmed/23569547 http://dx.doi.org/10.12659/AJCR.883584 Text en © Am J Case Rep, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Case Report
Luks, Sophie
Simon, Rochelle A.
Lawrence, W. Dwayne
Arias-Stella reaction of the cervix: The enduring diagnostic challenge
title Arias-Stella reaction of the cervix: The enduring diagnostic challenge
title_full Arias-Stella reaction of the cervix: The enduring diagnostic challenge
title_fullStr Arias-Stella reaction of the cervix: The enduring diagnostic challenge
title_full_unstemmed Arias-Stella reaction of the cervix: The enduring diagnostic challenge
title_short Arias-Stella reaction of the cervix: The enduring diagnostic challenge
title_sort arias-stella reaction of the cervix: the enduring diagnostic challenge
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614382/
https://www.ncbi.nlm.nih.gov/pubmed/23569547
http://dx.doi.org/10.12659/AJCR.883584
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