Cargando…
Arias-Stella reaction of the cervix: The enduring diagnostic challenge
BACKGROUND: The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia. When presenting in extra-uterine sites, the differentiati...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614382/ https://www.ncbi.nlm.nih.gov/pubmed/23569547 http://dx.doi.org/10.12659/AJCR.883584 |
_version_ | 1782264834587361280 |
---|---|
author | Luks, Sophie Simon, Rochelle A. Lawrence, W. Dwayne |
author_facet | Luks, Sophie Simon, Rochelle A. Lawrence, W. Dwayne |
author_sort | Luks, Sophie |
collection | PubMed |
description | BACKGROUND: The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia. When presenting in extra-uterine sites, the differentiation of Arias-Stella changes from other more ominous clear cell lesions may pose significant difficulties. CASE REPORT: We report a case of an endocervical clear cell lesion incidentally discovered during a prenatal visit of a young pregnant woman. Interpretation of the pathological findings was complicated by the small size and fragmentation of the specimen. CONCLUSIONS: Recognition of Arias-Stella reaction in extra-uterine sites, especially in young women, is critical to avoid misdiagnosis of this innocuous lesion as clear cell adenocarcinoma. Attention to cellular and nuclear detail, as well as careful consideration of the clinical scenario, is crucial for establishment of the correct diagnosis. |
format | Online Article Text |
id | pubmed-3614382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36143822013-04-08 Arias-Stella reaction of the cervix: The enduring diagnostic challenge Luks, Sophie Simon, Rochelle A. Lawrence, W. Dwayne Am J Case Rep Case Report BACKGROUND: The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia. When presenting in extra-uterine sites, the differentiation of Arias-Stella changes from other more ominous clear cell lesions may pose significant difficulties. CASE REPORT: We report a case of an endocervical clear cell lesion incidentally discovered during a prenatal visit of a young pregnant woman. Interpretation of the pathological findings was complicated by the small size and fragmentation of the specimen. CONCLUSIONS: Recognition of Arias-Stella reaction in extra-uterine sites, especially in young women, is critical to avoid misdiagnosis of this innocuous lesion as clear cell adenocarcinoma. Attention to cellular and nuclear detail, as well as careful consideration of the clinical scenario, is crucial for establishment of the correct diagnosis. International Scientific Literature, Inc. 2012-11-19 /pmc/articles/PMC3614382/ /pubmed/23569547 http://dx.doi.org/10.12659/AJCR.883584 Text en © Am J Case Rep, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Case Report Luks, Sophie Simon, Rochelle A. Lawrence, W. Dwayne Arias-Stella reaction of the cervix: The enduring diagnostic challenge |
title | Arias-Stella reaction of the cervix: The enduring diagnostic challenge |
title_full | Arias-Stella reaction of the cervix: The enduring diagnostic challenge |
title_fullStr | Arias-Stella reaction of the cervix: The enduring diagnostic challenge |
title_full_unstemmed | Arias-Stella reaction of the cervix: The enduring diagnostic challenge |
title_short | Arias-Stella reaction of the cervix: The enduring diagnostic challenge |
title_sort | arias-stella reaction of the cervix: the enduring diagnostic challenge |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614382/ https://www.ncbi.nlm.nih.gov/pubmed/23569547 http://dx.doi.org/10.12659/AJCR.883584 |
work_keys_str_mv | AT lukssophie ariasstellareactionofthecervixtheenduringdiagnosticchallenge AT simonrochellea ariasstellareactionofthecervixtheenduringdiagnosticchallenge AT lawrencewdwayne ariasstellareactionofthecervixtheenduringdiagnosticchallenge |