Double-ligand modulation for engineering magnetic nanoclusters

Magnetic nanoclusters (MNCs) are agglomerated individual magnetic nanoparticles (MNPs) that show great promise in increasing magnetic resonance imaging (MRI) sensitivity. Here, we report an effective strategy to engineer MNCs based on double-ligand modulation to enhance MRI sensitivity. The oleic ac...

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Detalles Bibliográficos
Autores principales: Kim, Bongjune, Yang, Jaemoon, Lim, Eun-Kyung, Park, Joseph, Suh, Jin-Suck, Park, Hyo Seon, Huh, Yong-Min, Haam, Seungjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614429/
https://www.ncbi.nlm.nih.gov/pubmed/23433032
http://dx.doi.org/10.1186/1556-276X-8-104
Descripción
Sumario:Magnetic nanoclusters (MNCs) are agglomerated individual magnetic nanoparticles (MNPs) that show great promise in increasing magnetic resonance imaging (MRI) sensitivity. Here, we report an effective strategy to engineer MNCs based on double-ligand modulation to enhance MRI sensitivity. The oleic acid-coated individual MNPs self-assembled and then were enveloped by polysorbate 80, using a nanoemulsion method to prepare MNCs. By modulating the amounts of the two ligands, and thus the size and magnetic content of the resultant MNCs, we were able to enormously improve MRI sensitivity.

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