Research on Hereditability of Gastric Cancer in Wuwei City

AIM: To explore hereditability of gastric cancer in Wuwei city. METHODS: A case-control study was used to investigate 251 gastric cancer families located in Wuwei city. Li-Mantel-Gan and Falconer regression methods were used to calculate segregation ratios and hereditability. RESULTS: The segregatio...

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Detalles Bibliográficos
Autores principales: Mi, Deng-Hai, Chen, Xue-Peng, Luo, Hao-Zeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614574/
https://www.ncbi.nlm.nih.gov/pubmed/23674969
Descripción
Sumario:AIM: To explore hereditability of gastric cancer in Wuwei city. METHODS: A case-control study was used to investigate 251 gastric cancer families located in Wuwei city. Li-Mantel-Gan and Falconer regression methods were used to calculate segregation ratios and hereditability. RESULTS: The segregation ratio in Wuwei families was 0.0774, the hereditability of class I kinfolks and class II kinfolks were respectively 22.91% and 20.07%. CONCLUSION: The segregation ratio of gastric cancer in Wuwei was significantly lower than for mono-genetic diseases (0.25), corresponding better with a model of polygenetic diseases. The genetic susceptibility factor accounted for about 1/5-1/4 in the formation of gastric cancer familial aggregation. Mi DH, Chen XP, Luo HZ Research on hereditability of gastric cancer in Wuwei city.

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