Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay

In view of potential biological activities of some succinic acid derivatives, we synthesized some novel N-[4-(4-morpholinosulfonyl)-phenyl]-succinamides (6a, c; 7a, c) and N-[4-(benzylaminosulfonyl) phenyl]-succinamides (6b, d; 7b, d) derivatives as antitumor agents. The antitumor activity of compou...

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Detalles Bibliográficos
Autores principales: Hadizadeh, Farzin, Moradi, Alireza, Naghibi, Goli, Vojdani, Mojgan, Behravan, Javad, Ramezani, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614617/
https://www.ncbi.nlm.nih.gov/pubmed/23675023
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author Hadizadeh, Farzin
Moradi, Alireza
Naghibi, Goli
Vojdani, Mojgan
Behravan, Javad
Ramezani, Mohammad
author_facet Hadizadeh, Farzin
Moradi, Alireza
Naghibi, Goli
Vojdani, Mojgan
Behravan, Javad
Ramezani, Mohammad
author_sort Hadizadeh, Farzin
collection PubMed
description In view of potential biological activities of some succinic acid derivatives, we synthesized some novel N-[4-(4-morpholinosulfonyl)-phenyl]-succinamides (6a, c; 7a, c) and N-[4-(benzylaminosulfonyl) phenyl]-succinamides (6b, d; 7b, d) derivatives as antitumor agents. The antitumor activity of compounds was studied using the potato disk bioassay technique. Vincristine at 0.25 mg/ml was employed as positive control and caused -67.24% inhibitions. Compound 7b at 1 mg/ml caused -80.50% tumor inhibitions with highest activity among compounds tested.
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spelling pubmed-36146172013-05-01 Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay Hadizadeh, Farzin Moradi, Alireza Naghibi, Goli Vojdani, Mojgan Behravan, Javad Ramezani, Mohammad Int J Biomed Sci Article In view of potential biological activities of some succinic acid derivatives, we synthesized some novel N-[4-(4-morpholinosulfonyl)-phenyl]-succinamides (6a, c; 7a, c) and N-[4-(benzylaminosulfonyl) phenyl]-succinamides (6b, d; 7b, d) derivatives as antitumor agents. The antitumor activity of compounds was studied using the potato disk bioassay technique. Vincristine at 0.25 mg/ml was employed as positive control and caused -67.24% inhibitions. Compound 7b at 1 mg/ml caused -80.50% tumor inhibitions with highest activity among compounds tested. Master Publishing Group 2007-03 /pmc/articles/PMC3614617/ /pubmed/23675023 Text en © Farzin Hadizadeh et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Hadizadeh, Farzin
Moradi, Alireza
Naghibi, Goli
Vojdani, Mojgan
Behravan, Javad
Ramezani, Mohammad
Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay
title Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay
title_full Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay
title_fullStr Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay
title_full_unstemmed Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay
title_short Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay
title_sort synthesis and antitumor activity of substituted succinamides using a potato disc tumor induction assay
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614617/
https://www.ncbi.nlm.nih.gov/pubmed/23675023
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