Antibacterial Activity of Synthetic Precursors of Podophyllotoxin

Precursors of podophyllotoxin were synthesized and screened for their antibacterial activity. The results proved that ethyl-2-(3′-methyl-4′-methoxybenzoyl)-3-(4″ methoxyphenol)-cyclopropane-1-carboxylic acid and Ethyl-2-(3′-methyl-4′-methoxybenzyol-3-1 3″, 4″-dimethoxyphenyl)-cyclopropane-carboxylic...

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Autores principales: Nanjundaswamy, N., Satishi, S., Lokanatha Rai, K. M., Shashikanth, S., Raveesha, K. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614634/
https://www.ncbi.nlm.nih.gov/pubmed/23675032
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author Nanjundaswamy, N.
Satishi, S.
Lokanatha Rai, K. M.
Shashikanth, S.
Raveesha, K. A.
author_facet Nanjundaswamy, N.
Satishi, S.
Lokanatha Rai, K. M.
Shashikanth, S.
Raveesha, K. A.
author_sort Nanjundaswamy, N.
collection PubMed
description Precursors of podophyllotoxin were synthesized and screened for their antibacterial activity. The results proved that ethyl-2-(3′-methyl-4′-methoxybenzoyl)-3-(4″ methoxyphenol)-cyclopropane-1-carboxylic acid and Ethyl-2-(3′-methyl-4′-methoxybenzyol-3-1 3″, 4″-dimethoxyphenyl)-cyclopropane-carboxylic acid have significant antibacterial activity against Citrobacter sp., Escherchia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella sonnei and Streptococcus faecalis. The activity is lower than Ciprofloxacin and equal to Gentamicin and more than Penicillin and Streptomycin.
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spelling pubmed-36146342013-05-01 Antibacterial Activity of Synthetic Precursors of Podophyllotoxin Nanjundaswamy, N. Satishi, S. Lokanatha Rai, K. M. Shashikanth, S. Raveesha, K. A. Int J Biomed Sci Article Precursors of podophyllotoxin were synthesized and screened for their antibacterial activity. The results proved that ethyl-2-(3′-methyl-4′-methoxybenzoyl)-3-(4″ methoxyphenol)-cyclopropane-1-carboxylic acid and Ethyl-2-(3′-methyl-4′-methoxybenzyol-3-1 3″, 4″-dimethoxyphenyl)-cyclopropane-carboxylic acid have significant antibacterial activity against Citrobacter sp., Escherchia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella sonnei and Streptococcus faecalis. The activity is lower than Ciprofloxacin and equal to Gentamicin and more than Penicillin and Streptomycin. Master Publishing Group 2007-06 /pmc/articles/PMC3614634/ /pubmed/23675032 Text en © Nanjundaswamy et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Nanjundaswamy, N.
Satishi, S.
Lokanatha Rai, K. M.
Shashikanth, S.
Raveesha, K. A.
Antibacterial Activity of Synthetic Precursors of Podophyllotoxin
title Antibacterial Activity of Synthetic Precursors of Podophyllotoxin
title_full Antibacterial Activity of Synthetic Precursors of Podophyllotoxin
title_fullStr Antibacterial Activity of Synthetic Precursors of Podophyllotoxin
title_full_unstemmed Antibacterial Activity of Synthetic Precursors of Podophyllotoxin
title_short Antibacterial Activity of Synthetic Precursors of Podophyllotoxin
title_sort antibacterial activity of synthetic precursors of podophyllotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614634/
https://www.ncbi.nlm.nih.gov/pubmed/23675032
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AT shashikanths antibacterialactivityofsyntheticprecursorsofpodophyllotoxin
AT raveeshaka antibacterialactivityofsyntheticprecursorsofpodophyllotoxin

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